Hydroxypropylmethylcellulose (HPMC) bụ polymer multifunctional nke a na-ejikarị na ụlọ ọrụ ọgwụ.Ọ bụ akụkụ nke ether cellulose ma sitere na cellulose eke.A na-emepụta HPMC site n'ịgwọ cellulose na propylene oxide na methyl chloride, na-ebute ogige ndị nwere mma solubility na ihe ndị ọzọ a na-achọsi ike.A na-eji ihe mgbakwunye ọgwụ a eme ihe n'ọtụtụ ebe na mmepe na imepụta ụdị usoro onunu ogwu dị iche iche, gụnyere mbadamba, capsules, nkwadebe anya na sistemụ nnyefe ọgwụ na-achịkwa.
Okwu mmalite nke hydroxypropyl methylcellulose:
Usoro na Njirimara:
Hydroxypropyl methylcellulose bụ ọkara sịntetik, inert, polymer soluble mmiri.Ọdịdị kemịkal ya gụnyere hydroxypropyl na methoxy dị iche iche jikọtara na ọkpụkpụ azụ cellulose.Ọnụọgụ ndị nọchiri anya ndị a nwere ike ịdị iche, na-ebute akara ule HPMC dị iche iche nwere ihe dị iche iche.Usoro ngbanwe ahụ na-emetụta paramita dị ka viscosity, solubility, na gel Njirimara.
Usoro mmepụta:
Mmepụta nke HPMC gụnyere etherification nke cellulose na propylene oxide na methyl chloride.Enwere ike ịchịkwa ogo nke nnọchi (DS) nke hydroxypropyl na otu methoxy n'oge njikọta, na-enye ohere ịkwa akwa akụrụngwa HPMC ka achọrọ imepụta ọgwụ.
Ngwa na ụlọ ọrụ ọgwụ:
Njide n'ụdị mbadamba nkume:
A na-eji HPMC eme ihe n'ọtụtụ ebe dị ka ihe nchikota n'ụdị mbadamba.Ihe ejikọtara ya na-enyere aka na ịpịkọta ntụ ntụ n'ime mbadamba nkume siri ike.Enwere ike nweta ntọhapụ a na-achịkwa nke ngwa ọgwụ na-arụ ọrụ (API) site na iji akara ule HPMC nwere ọkwa viscosity kwesịrị ekwesị na nnọchi.
Ihe mkpuchi ihe nkiri:
A na-eji HPMC dị ka ihe mkpuchi ihe nkiri maka mbadamba nkume na granules.Ọ na-enye mkpuchi nchebe otu nke na-eme ka ọdịdị ahụ dịkwuo mma, nkpuchi uto na nkwụsi ike nke ụdị usoro onunu ogwu.Ọzọkwa, mkpuchi nke HPMC nwere ike gbanwee profaịlụ ntọhapụ ọgwụ.
Ntọhapụ na-adịgide adịgide yana njikwa:
Ọdịdị hydrophilic nke polymer a na-eme ka ọ dị mma maka iji ya mee ihe n'usoro ntọhapụ na-adịgide adịgide na njikwa.Matrix HPMC na-enye ohere ịhapụ ọgwụ a na-achịkwa n'ime ogologo oge, na-eme ka nnabata ndị ọrịa na-ebelata ma na-ebelata ugboro ugboro.
Nkwadebe anya:
N'ụdị ophthalmic, a na-eji HPMC amụba viscosity nke anya mmiri, si otú ahụ na-enye ogologo oge obibi n'elu anya anya.Nke a na-eme ka bioavailability nke ọgwụ ahụ na ịdị irè ọgwụgwọ.
Ihe nkwụsi ike:
A na-eji HPMC eme ihe dị ka thickener na stabilizer na mmiri mmiri na ọkara siri ike usoro dị ka gels, creams na nkwusioru.Ọ na-enye viscosity na usoro ndị a ma na-emezi njirimara rheological ha n'ozuzu ya.
Isi atụmatụ nke HPMC:
Solubility:
HPMC bụ soluble n'ime mmiri ma mepụta ngwọta doro anya na enweghị agba.Ọkwa nke mgbasa na-emetụta ogo nke nnọchi na ọkwa viscosity.
Viscosity:
The viscosity nke HPMC ngwọta dị oké egwu na-ekpebi arụmọrụ ha na dị iche iche ngwa.Akara akara dị iche iche dị na viscosities dị iche iche, na-enye ohere ijikwa njikwa ziri ezi nke njirimara rheological nke nhazi ahụ.
Thermal gelation:
Ụfọdụ akara ule nke HPMC na-egosipụta njirimara thermogelling, na-akpụ gels na okpomọkụ dị elu.A na-eji ihe onwunwe a emepụta usoro ihe na-emetụ ọkụ.
ndakọrịta:
HPMC dakọtara na ọtụtụ ngwa ahịa ọgwụ na API, na-eme ka ọ bụrụ nhọrọ mbụ maka ndị na-emepụta ihe.Ọ naghị emeghachi omume na ma ọ bụ weda ọtụtụ ihe ndị na-arụ ọrụ.
Ihe ịma aka na echiche:
Hygroscopicity:
HPMC bụ hygroscopic, nke pụtara na ọ na-amịkọrọ mmiri sitere na gburugburu ebe obibi.Nke a na-emetụta nkwụsi ike na ọdịdị nke nhazi ahụ, ya mere a chọrọ ọnọdụ nchekwa kwesịrị ekwesị.
Ndakọrịta na ihe mgbakwunye ndị ọzọ:
Ọ bụ ezie na n'ozuzu dakọtara, formulators kwesịrị ịtụle ndakọrịta nke HPMC na ndị ọzọ excipients iji zere ndị nwere ike mmekọrịta nwere ike imetụta arụmọrụ nhazi.
Mmetụta dị na usoro mgbasa:
Nhọrọ nke akara HPMC nwere ike imetụta profaịlụ mgbasa nke ọgwụ.Onye na-emepụta ihe ga-eji nlezianya họrọ ọkwa kwesịrị ekwesị iji nweta njirimara ntọhapụ achọrọ.
Atụmatụ usoro iwu:
A nabatara HPMC n'ọtụtụ ebe dị ka ihe enyemaka ọgwụ dị mma ma dị irè.Ọ na-ezute ụkpụrụ nchịkwa dị iche iche ma tinye ya na pharmacopoeias gburugburu ụwa.Ndị na-emepụta ihe ga-agbasorịrị ụkpụrụ omume nrụpụta dị mma (GMP) iji hụ na ịdịmma na nkwekọ nke ngwaahịa ọgwụ nwere HPMC.
na ngwụcha:
Hydroxypropylmethylcellulose (HPMC), dị ka a vasatail na ọtụtụ ebe a excipient, na-arụ ọrụ dị mkpa na ụlọ ọrụ ọgwụ.Ngwongwo ya pụrụ iche na-eme ka ọ dị mma maka iji ya n'ụdị usoro ọgwụgwọ dị iche iche, gụnyere mbadamba nkume, capsules na nkwadebe ophthalmic.Ndị na-emepụta ihe na-erite uru site n'inwe ike ịhazi ihe onwunwe nke HPMC iji mezuo ihe achọrọ nhazi, dị ka ntọhapụ a na-achịkwa na nkwụsi ike ka mma.N'agbanyeghị nsogbu ụfọdụ, HPMC na-anọgide na-abụ isi ihe na-emepụta ngwaahịa ọgwụ dị elu, na-enye aka na nchekwa na nrụpụta nke ọtụtụ usoro ọgwụ.
Oge nzipu: Dec-15-2023