Hydroxypropyl methylcellulose (HPMC) bụ polymer a na-ejikarị eme ihe na ọgwụ, ihe ịchọ mma, ngwaahịa nri, na ngwa ụlọ ọrụ ndị ọzọ dị iche iche.A na-eji ya eme ihe n'ọtụtụ ebe n'ihi ịdị ndụ ya, enweghị nsí, yana ikike ịgbanwe ihe rheological nke ngwọta.Agbanyeghị, ọ dị mkpa ịghọta ka esi agbaze HPMC nke ọma iji jiri akụrụngwa ya rụọ ọrụ nke ọma.
Mmiri: HPMC na-agbaze nke ukwuu na mmiri, na-eme ka ọ bụrụ nhọrọ kachasị mma maka ọtụtụ ngwa.Agbanyeghị, ọnụego mgbasa nwere ike ịdịgasị iche dabere na ihe ndị dị ka okpomọkụ, pH, na ọkwa nke HPMC ejiri.
Ihe mgbaze Organic: Ihe mgbaze organic dị iche iche nwere ike igbari HPMC ruo oke dị iche iche.Ụfọdụ ihe mgbaze organic nkịtị gụnyere:
Mmanya na-aba n'anya: Isopropanol (IPA), ethanol, methanol, wdg. A na-ejikarị mmanya ndị a eme ihe na usoro ọgwụ ma nwee ike igbari HPMC nke ọma.
Acetone: Acetone bụ ihe mgbaze siri ike nke nwere ike igbari HPMC nke ọma.
Ethyl Acetate: Ọ bụ ihe mgbaze organic ọzọ nwere ike igbari HPMC nke ọma.
Chloroform: Chloroform bụ ihe mgbaze na-eme ihe ike na ekwesịrị iji nlezianya mee ihe n'ihi nsị ya.
Dimethyl Sulfoxide (DMSO): DMSO bụ ihe mgbaze polar aprotic nke nwere ike igbari ọtụtụ ogige, gụnyere HPMC.
Propylene Glycol (PG): A na-ejikarị PG eme ihe dị ka ihe mgbaze na usoro ọgwụ.Ọ nwere ike igbari HPMC nke ọma ma na-ejikarị ya na mmiri ma ọ bụ ihe mgbaze ndị ọzọ.
Glycerin: Glycerin, nke a makwaara dị ka glycerol, bụ ihe mgbaze na-emekarị na ọgwụ na ihe ịchọ mma.A na-ejikarị ya na mmiri na-agbari HPMC.
Polyethylene Glycol (PEG): PEG bụ polymer nwere ezigbo solubility na mmiri na ọtụtụ ihe mgbaze organic.Enwere ike iji ya gbazee HPMC ma a na-ejikarị ya n'ọrụ na usoro ntọhapụ na-adịgide adịgide.
Surfactants: Ụfọdụ surfactants nwere ike inye aka na mgbasa nke HPMC site na ibelata esemokwu elu na imezi wetting.Ọmụmaatụ gụnyere Tween 80, sodium lauryl sulfate (SLS), na polysorbate 80.
Acid siri ike ma ọ bụ ntọala: Ọ bụ ezie na anaghị ejikarị ya n'ihi nchegbu nchekwa yana mmebi nke HPMC, acid siri ike (dịka ọmụmaatụ, hydrochloric acid) ma ọ bụ ntọala (dịka, sodium hydroxide) nwere ike igbari HPMC n'okpuru ọnọdụ kwesịrị ekwesị.Agbanyeghị, ọnọdụ pH dị oke egwu nwere ike ibute mmebi nke polymer.
Ndị na-agbagwoju anya: Ụfọdụ ihe mgbagwoju anya dị ka cyclodextrins nwere ike ịmepụta ogige nsonye na HPMC, na-enyere aka n'ịgbasa ya na ịkwalite ike ya.
Okpomọkụ: N'ozuzu, okpomọkụ dị elu na-akwalite ọnụego mgbasa nke HPMC na ihe mgbaze dị ka mmiri.Agbanyeghị, oke okpomoku dị elu nwere ike mebie polymer, yabụ na ọ dị mkpa iji rụọ ọrụ n'ime oke okpomọkụ dị mma.
Mechanical Agitation: ịkpali ma ọ bụ ịgwakọta nwere ike ikwado mgbasa nke HPMC site na ịba ụba kọntaktị n'etiti polymer na ihe mgbaze.
Oke urughuru: HPMC nke nwere ntụ ntụ ga-agbaze ngwa ngwa karịa irighiri ihe buru ibu n'ihi oke elu.
Ọ dị mkpa iburu n'uche na nhọrọ nke ihe mgbaze na ọnọdụ mgbasa na-adabere na ngwa a kapịrị ọnụ yana njirimara achọrọ nke ngwaahịa ikpeazụ.Ndakọrịta na ihe ndị ọzọ, nchekwa nchekwa, na ihe ndị chọrọ n'iwu na-emetụtakwa nhọrọ nke ihe mgbaze na ụzọ mgbasa.Na mgbakwunye, ọ dị mkpa iji duzie ọmụmụ ndakọrịta yana nnwale nkwụsi ike iji hụ na usoro mgbasa anaghị emetụta ogo ma ọ bụ arụmọrụ nke ngwaahịa ikpeazụ.
Oge nzipu: Mar-22-2024