Hydroxypropyl methylcellulose (HPMC) bụ polymer vasatail nke a na-ejikarị eme ihe na ụlọ ọrụ dị iche iche, gụnyere ọgwụ, ihe ịchọ mma, nri, na ihe owuwu.Ikike ya ịmepụta gels, ihe nkiri, na ngwọta na-eme ka ọ baa uru maka ọtụtụ ngwa.Hydration nke HPMC bụ nzọụkwụ dị oke mkpa n'ọtụtụ usoro, ebe ọ na-enyere polymer aka igosipụta akụrụngwa ọ chọrọ nke ọma.
1. Ịghọta HPMC:
HPMC bụ ihe sitere na cellulose ma na-emepụta ya site n'ịgwọ cellulose na propylene oxide na methyl chloride.A na-akọwa ya site na mmiri-soluble ya na ike ịmepụta transperent, thermally reversible gels.Ogo nke hydroxypropyl na methoxyl na-emetụta akụrụngwa ya, gụnyere solubility, viscosity, na omume gelation.
2. Mkpa nke hydration:
hydration dị mkpa iji kpọghee ọrụ HPMC.Mgbe HPMC na-agba mmiri, ọ na-amịkọrọ mmiri ma zaa, na-eduga n'ịmepụta ngwọta viscous ma ọ bụ gel, dabere na ntinye na ọnọdụ.Ọnọdụ mmiri mmiri a na-enyere HPMC aka ịrụ ọrụ ndị e bu n'obi rụọ, dị ka ịgbara úkwù, gelling, imepụta ihe nkiri, na ịkwado ntọhapụ ọgwụ.
3. Ụzọ nke hydration:
Enwere ọtụtụ ụzọ maka hydrating HPMC, dabere na ngwa na nsonaazụ achọrọ:
a.Mgbasa mmiri oyi:
Usoro a gụnyere ịgbasa ntụ ntụ HPMC na mmiri oyi ka ọ na-akpali akpali.
A na-ahọrọ ịgbasa mmiri oyi iji gbochie ịchịkọta ma hụ na mmiri dị n'otu.
Mgbe mgbasasịrị, a na-ahapụ ihe ngwọta ahụ ka ọ na-agbaba n'ihu n'okpuru mkpasu iwe iji nweta viscosity achọrọ.
b.Mgbasa mmiri dị ọkụ:
Na usoro a, HPMC ntụ ntụ na-agbasasị na mmiri ọkụ, ọ na-adịkarị na okpomọkụ karịa 80 Celsius.
Mmiri na-ekpo ọkụ na-eme ka hydration ngwa ngwa na mgbasa nke HPMC, na-ebute ngwọta doro anya.
Ekwesịrị ịkpachapụ anya ka ịzena oke ikpo ọkụ, nke nwere ike weda HPMC ma ọ bụ mee ka ọkpụkpụ kpụọ.
c.Nnọpụiche:
Ngwa ụfọdụ nwere ike ịgụnye iwepu ihe ngwọta HPMC yana ndị ọrụ alkaline dị ka sodium hydroxide ma ọ bụ potassium hydroxide.
Neutralization na-edozi pH nke ngwọta, nke nwere ike imetụta viscosity na gelation Njirimara nke HPMC.
d.Ngbanwe ihe mgbaze:
HPMC nwekwara ike hydrated site mgbaze mgbanwe, ebe ọ na-agbasasị na mmiri-miscible mgbaze dị ka ethanol ma ọ bụ methanol na mgbe ahụ gbanwere na mmiri.
Ngbanwe ihe mgbaze nwere ike ịba uru maka ngwa chọrọ njikwa ziri ezi maka hydration na viscosity.
e.Tupu aṅụ mmiri:
Tupu hydration na-agụnye itinye HPMC na mmiri ma ọ bụ ihe mgbaze tupu etinye ya n'ime usoro.
Usoro a na-eme ka hydration zuru oke ma nwee ike ịba uru maka ị nweta nsonaazụ na-agbanwe agbanwe, karịsịa na usoro mgbagwoju anya.
4. Ihe na-emetụta hydration:
Ọtụtụ ihe na-emetụta hydration nke HPMC:
a.Oke urughuru: HPMC ntụ ntụ na-egweri nke ọma hydrates ngwa ngwa karịa irighiri irighiri uru n'ihi ụbara elu.
b.Okpomọkụ: Okpomọkụ dị elu na-eme ngwa ngwa hydration mana ọ nwekwara ike imetụta viscosity na omume gelation nke HPMC.
c.pH: The pH nke hydration media nwere ike imetụta ọnọdụ ionization nke HPMC na N'ihi ya hydration kinetics na rheological Njirimara.
d.Ịgwakọta: Ịgwakọta ma ọ bụ mkpasu iwe kwesịrị ekwesị dị oké mkpa maka otu hydration na mgbasa nke ụmụ irighiri ihe HPMC na ihe mgbaze.
e.Ntụkwasị obi: Ntinye uche nke HPMC na hydration media na-emetụta viscosity, ike gel, na ihe ndị ọzọ nke ngwọta ma ọ bụ gel pụta.
5. Ngwa:
Hydrated HPMC na-achọta ngwa dị iche iche n'ofe ụlọ ọrụ dị iche iche:
a.Usoro ọgwụ: N'ime mkpuchi mbadamba, matrices mwepụta a na-achịkwa, ngwọta anya, na nkwusioru.
b.Ngwaahịa Nri: Dị ka onye na-agbapụta, stabilizer, ma ọ bụ onye na-emepụta ihe nkiri na nri, akwa akwa, ngwaahịa mmiri ara ehi, na ihe oriri.
c.Ihe ịchọ mma: Na ude, lotions, gels, na usoro ndị ọzọ maka mgbanwe viscosity na emulsification.
d.Ihe eji arụ ọrụ: N'ime ngwaahịa simenti, ihe ntanye tile, na ihe na-eme ka ọ dịkwuo mma ịrụ ọrụ, njide mmiri, na nchikota.
6. Njikwa ogo:
hydration dị mma nke HPMC dị oke mkpa maka ịrụ ọrụ ngwaahịa yana nkwụsi ike.Usoro njikwa ogo nwere ike ịgụnye:
a.Nyocha nha urughuru: Ịhụ na ịdị n'otu nke nkesa nha urughuru na-ebuli kinetics hydration.
b.Ntụle viscosity: Nleba anya viscosity n'oge hydration iji nweta nkwekọ achọrọ maka ngwa ezubere.
c.Nleba anya pH: Ịchịkwa pH nke usoro hydration iji kwalite hydration ma gbochie mmebi.
d.Nyocha microscopic: Nlele anya nke ihe atụ hydrated n'okpuru microscope iji chọpụta mgbasasa na iguzosi ike n'ezi ihe.
7. Nkwubi okwu:
Hydration bụ usoro dị mkpa na ijikwa akụrụngwa nke HPMC maka ngwa dị iche iche.Ịghọta ụzọ, ihe, na usoro njikwa mma jikọtara ya na hydration dị mkpa maka ịkwalite arụmọrụ ngwaahịa yana hụ na ọ na-agbanwe agbanwe na nhazi.Site n'ịmụta hydration nke HPMC, ndị na-eme nchọpụta na ndị na-emepụta ihe nwere ike imeghe ike ya n'ofe ụlọ ọrụ dịgasị iche iche, mmepụta ihe ọhụrụ na mmepụta ngwaahịa.
Oge nzipu: Mar-04-2024