Ihe mkpuchi ihe nkiri bụ usoro dị oke mkpa n'ichepụta ọgwụ, ebe a na-etinye obere polymer n'elu mbadamba nkume ma ọ bụ capsules.Ihe mkpuchi a na-arụ ọrụ dị iche iche, gụnyere imeziwanye ọdịdị ahụ, ịmachi uto, ichebe ọgwụ ọgwụ na-arụ ọrụ (API), ịchịkwa ntọhapụ, na ịkwado ilo.Hydroxypropyl Methylcellulose (HPMC) bụ otu n'ime polymers ndị a na-ejikarị eme ihe na mkpuchi ihe nkiri n'ihi njirimara ya.
1. Njirimara nke HPMC:
Hydroxypropyl Methylcellulose (HPMC) bụ polymer synthetic nke sitere na cellulose.A na-akọwa ya site na mmiri-solubility ya, ikike imepụta ihe nkiri, yana ezigbo ndakọrịta na ihe dị iche iche ọgwụ.Enwere ike ịhazi njirimara nke HPMC site na ịmegharị paramita dị ka ịdị arọ molekụla, ogo nke nnọchi, na viscosity.
Ikike imepụta ihe nkiri: HPMC nwere ihe na-emepụta ihe nkiri dị mma, na-eme ka e guzobe otu akwa na mkpuchi dị larịị n'elu ụdị usoro onunu ogwu.
Mmiri Solubility: HPMC na-egosiputa mmiri-soluble, na-enye ohere maka mgbasa nke polymer na ngwọta mmiri n'oge usoro mkpuchi.Ngwongwo a na-eme ka nkesa otu nke polymer na-eme ka ọ dị mfe ịmepụta oyi akwa mkpuchi ọnụ.
Adhesion: HPMC na-egosiputa nrapanye dị mma n'elu mbadamba nkume ma ọ bụ capsules, na-eme ka mkpuchi na-adịgide adịgide na-agbaso nke ọma na mkpụrụ.
Ihe mgbochi: HPMC na-enye ihe mgbochi megide ihe gburugburu ebe obibi dị ka mmiri, oxygen, na ìhè, si otú ahụ na-echebe iguzosi ike n'ezi ihe nke ụdị usoro onunu ogwu na ịkwalite nkwụsi ike.
2. Atụmatụ nhazi:
N'ịmepụta ihe ngwọta mkpuchi ihe nkiri site na iji HPMC, a ga-atụle ọtụtụ ihe iji nweta njirimara mkpuchi na arụmọrụ achọrọ.
Ntụle Polymer: Ntụle nke HPMC na ngwọta mkpuchi na-emetụta oke na ihe eji arụ ọrụ nke ihe nkiri ahụ.Ngwunye polymer dị elu na-ebute mkpuchi siri ike nwere ihe mgbochi emelitere.
Ndị na-emepụta ihe: Mgbakwunye nke ndị na-emepụta ihe dị ka polyethylene glycol (PEG) ma ọ bụ propylene glycol (PG) nwere ike ime ka mgbanwe na mgbanwe nke mkpuchi ahụ dịkwuo mma, na-eme ka ọ ghara ịdị nro ma na-eguzogide ọgwụ.
Ihe mgbaze: Nhọrọ nke ihe mgbaze kwesịrị ekwesị dị oke mkpa iji hụ na solubility nke HPMC na nhazi ihe nkiri kwesịrị ekwesị.Ihe mgbaze nkịtị gụnyere mmiri, ethanol, isopropanol, na ngwakọta ya.
Pigments na Opacifiers: Ntinye nke pigmenti na opacifiers n'ime ihe mkpuchi nwere ike inye agba, meziwanye ọdịdị, ma nye nchebe ọkụ na ọgwụ ndị nwere mmetụta.
3. Ngwa nke HPMC na mkpuchi ihe nkiri:
Ihe mkpuchi nke HPMC na-achọta ngwa ngwa dị ukwuu na ụlọ ọrụ ọgwụ na ọgwụ na-edozi ahụ n'ihi ngbanwe ha na dabara adaba maka ụdị usoro onunu ogwu dị iche iche.
Mwepu mwepụta ozugbo: Enwere ike iji mkpuchi HPMC wepụta mwepụta ọgwụ ozugbo site n'ịchịkwa mgbasa na ọnụego mgbaze nke mbadamba nkume ma ọ bụ capsules.
Mkpuchi Mwepụta gbanwegharịrị: A na-ejikarị ụdị usoro HPMC arụ ọrụ n'ụdị ntọhapụ gbanwetụrụ, gụnyere ntọhapụ-agbatị na usoro mkpuchi ime.Site n'ịgbanwe viscosity na ọkpụrụkpụ nke mkpuchi ahụ, enwere ike ịhazi profaịlụ ntọhapụ nke ọgwụ ahụ iji nweta ntọhapụ na-adịgide adịgide ma ọ bụ nke ezubere iche.
Ikpuchi ire ụtọ: mkpuchi HPMC nwere ike kpuchie uto ọgwụ na-adịghị mma, na-eme ka nnabata ndị ọrịa na nnabata nke ụdị usoro onunu.
Nchekwa mmiri: Mkpuchi HPMC na-enye nchebe mmiri dị mma, ọkachasị maka ọgwụ hygroscopic na-enwekarị mbibi mgbe ikpughe na mmiri.
Nkwalite nkwụsi ike: mkpuchi HPMC na-enye ihe mgbochi megide ihe gburugburu ebe obibi, si otú ahụ na-eme ka nkwụsi ike na ndụ nke ngwaahịa ọgwụ.
Hydroxypropyl Methylcellulose (HPMC) na-arụ ọrụ dị mkpa na ngwa mkpuchi ihe nkiri na ụlọ ọrụ ọgwụ.Ngwongwo ya pụrụ iche, gụnyere ikike imepụta ihe nkiri, mmiri solubility, adhesion, na ihe mgbochi, na-eme ka ọ bụrụ nhọrọ dị mma maka ịmepụta mkpuchi nwere ọrụ dị iche iche.Site n'ịghọta atụmatụ nhazi na ngwa nke HPMC na mkpuchi ihe nkiri, ndị na-emepụta ọgwụ nwere ike ịmepụta ụdị usoro onunu ogwu na arụmọrụ kwalite, nkwụsi ike, na nnabata onye ọrịa.
Oge nzipu: Mar-07-2024