Isi ihe na-emetụta njide mmiri nke HPMC

Hydroxypropylmethylcellulose (HPMC), dị ka polymer hydrophilic a na-ejikarị eme ihe na ụlọ ọrụ ọgwụ, a na-eji ya eme ihe na mkpuchi mbadamba, usoro ntọhapụ a na-achịkwa na usoro nnyefe ọgwụ ndị ọzọ.Otu n'ime ihe ndị bụ isi nke HPMC bụ ikike ya idowe mmiri, nke na-emetụta arụmọrụ ya dị ka ihe na-emepụta ọgwụ.N'isiokwu a, anyị ga-enyocha isi ihe na-emetụta njide mmiri nke HPMC, gụnyere ịdị arọ molecular, ụdị nnọchi, ntinye uche, na pH.

molekụla arọ

Arọ molikula nke HPMC na-arụ ọrụ dị oke mkpa n'ịchọpụta ike njide mmiri ya.N'ozuzu, elu molekụla arọ HPMC bụ ihe hydrophilic karịa ala molekul arọ HPMC na ike banye ọzọ mmiri.Nke a bụ n'ihi na HPMC dị arọ nke molekul nwere ogologo agbụ nke nwere ike ịgbakọta ma mepụta netwọk ka ukwuu, na-abawanye ụba mmiri nke enwere ike itinye uche.Agbanyeghị, ekwesịrị iburu n'uche na oke ibu molekụla HPMC ga-ebute nsogbu dị ka viscosity na isi ike nhazi.

ọzọ

Ihe ọzọ na-emetụta ikike njigide mmiri nke HPMC bụ ụdị ngbanwe.HPMC n'ozuzu na-abịa n'ụdị abụọ: hydroxypropyl-anọchi na methoxy-dochie.Ụdị dochie anya hydroxypropyl nwere ikike nnabata mmiri dị elu karịa ụdị dochie methoxy.Nke a bụ n'ihi na otu hydroxypropyl dị na molekul HPMC bụ hydrophilic ma na-abawanye mmekọrịta nke HPMC maka mmiri.N'ụzọ dị iche, ụdị nke methoxy dochie anya bụ obere hydrophilic ya mere ọ nwere ikike ijide mmiri dị ala.Ya mere, a ga-eji nlezianya họrọ ụdị HPMC ndị ọzọ dabere na njirimara achọrọ nke ngwaahịa ikpeazụ.

tinye uche na

Ịta ahụhụ nke HPMC na-emetụtakwa ikike ijide mmiri ya.N'ebe dị ala, HPMC anaghị emepụta ihe dị ka gel, ya mere ikike ijide mmiri ya dị ala.Ka mkpokọta HPMC na-abawanye, ụmụ irighiri ihe ndị polymer malitere ịbanye, na-akpụ ihe dị ka gel.Netwọk gel a na-amịkọrọ ma na-ejigide mmiri, na ikike njigide mmiri nke HPMC na-abawanye na ntinye uche.Otú ọ dị, e kwesịrị ịrịba ama na oke ịta nke HPMC ga-eduga ná nhazi nsogbu dị ka viscosity na nhazi ihe isi ike.Ya mere, ntinye nke HPMC eji eme ihe kwesiri ka emeziwanye ya iji nweta ikike njigide mmiri a choro ma zere nsogbu ndi a kpọtụrụ aha n'elu.

PH uru

Uru pH nke gburugburu ebe a na-eji HPMC ga-emetụtakwa ikike ijide mmiri ya.Usoro HPMC nwere otu anionic (-COO-) na otu hydrophilic ethylcellulose (-OH).The ionization nke -COO- otu bụ pH dabere, na ha ionization ogo na-abawanye na pH.Ya mere, HPMC nwere ikike njigide mmiri dị elu na pH dị elu.Na pH dị ala, a na-emepụta -COO- otu na hydrophilicity ya na-ebelata, na-eme ka ikike ijide mmiri dị ala.Ya mere, ekwesịrị ịkwalite pH gburugburu ebe obibi iji nweta ikike njigide mmiri achọrọ nke HPMC.

na ngwụcha

N'ikpeazụ, ike njide mmiri nke HPMC bụ isi ihe na-emetụta arụmọrụ ya dị ka ihe na-emepụta ọgwụ.Ihe ndị bụ isi na-emetụta ikike njide mmiri nke HPMC gụnyere ịdị arọ molecular, ụdị nnọchi, ntinye uche na uru pH.Site n'iji nlezianya dozie ihe ndị a, enwere ike ịkwalite ikike njigide mmiri nke HPMC iji nweta ihe ndị a chọrọ nke ngwaahịa njedebe.Ndị na-eme nchọpụta ọgwụ na ndị na-emepụta ọgwụ kwesịrị ịṅa ntị nke ọma na ihe ndị a iji hụ na àgwà kachasị elu na arụmọrụ nke usoro ọgwụ dabeere na HPMC.