Uru nke HPMC (hydroxypropyl methylcellulose) na ụlọ ọrụ ọgwụ na-egosipụta n'ọtụtụ akụkụ, na ihe ndị pụrụ iche ya na-eme ka ọ bụrụ ihe eji eme ihe n'ọtụtụ ebe.
1. Magburu onwe thickening na gelling Njirimara
HPMC bụ ihe na-eme ka mmiri na-agbaze mmiri nke nwere ihe na-eme ka ọ dị mma na ihe nkedo gelling. N'ichepụta ọgwụ, HPMC nwere ike iji dị ka onye na-ahụ maka thickener na gelling iji meziwanye viscosity na nkwụsi ike nke nkwadebe. Nke a dị mkpa karịsịa maka nkwadebe mmiri (dị ka mmiri mmiri na mmiri na-edozi ahụ), nke nwere ike imeziwanye njirimara rheological nke ọgwụ ahụ ma hụ na ịdị n'otu na nkwụsi ike.
2. Biocompatibility
HPMC nwere ezigbo bioacompatibility na biodegradability ma dabara adaba maka iji ya na ụlọ ọrụ ọgwụ, ọkachasị maka nkwadebe nke nkwadebe ọnụ na injections. N'ihi na a na-enweta ya site na osisi, HPMC adịghị egbu egbu ma ghara imerụ ahụ mmadụ, na-ebelata ihe ize ndụ nke mmeghachi omume ọgwụ ọjọọ.
3. Njirimara ntọhapụ na-achịkwa
A na-ejikarị HPMC akwado nkwado ntọhapụ a na-achịkwa yana ntọhapụ ọgwụ. Njirimara hydration ya nwere ike ịhazi ọnụego ntọhapụ nke ọgwụ ahụ, nweta ntọhapụ ọgwụ na-adịgide adịgide, belata oge nchịkwa, ma melite nnabata onye ọrịa. Ihe onwunwe a dị mkpa karịsịa na ọgwụgwọ ọrịa ndị na-adịghị ala ala, dị ka ọbara mgbali elu na ọrịa shuga.
4. Ezigbo solubility na nkwụsi ike
HPMC na-adị mfe mgbaze na mmiri ma nwee ike ịnọgidesi ike n'okpuru ọnọdụ pH dị iche iche. Nke a na-enye ya ohere iji ya mee ihe n'ọtụtụ ebe dị iche iche nke nkwadebe ọgwụ. Ma na gburugburu acidic ma ọ bụ alkaline, HPMC nwere ike ịnọgide na-arụ ọrụ ya ma hụ na nkwụsi ike nke ọgwụ.
5. Kwalite bioavailability nke ọgwụ
HPMC nwere ike melite bioavailability nke ụfọdụ ọgwụ, karịsịa maka ọgwụ ndị na-adịghị ike soluble. Site na ijikọta ọgwụ, HPMC nwere ike melite absorption nke ọgwụ n'ime ahụ ma welie mmetụta ọgwụgwọ ahụ. Nke a dị oke mkpa maka mmepe nke ọgwụ ọhụrụ, karịsịa obere ọgwụ molecule na ọgwụ nje.
6. Magburu onwe formability
Na usoro ọgwụ, HPMC nwere ike iji dị ka ihe nkedo na nkwadebe nke mbadamba nkume na capsules iji welie formability na ike nke nkwadebe. Ọ nwere ike melite mkpakọ nke ọgwụ ahụ, hụ na ịdị n'otu na nkwụsi ike nke mbadamba nkume ahụ, ma belata ọnụ ọgụgụ nkewa.
7. Ngwa ngwa ngwa
HPMC dakọtara na ọgwụ dịgasị iche iche ma na-ejikarị ya eme ihe n'ụdị dị iche iche dị ka mbadamba nkume, capsules, ngwọta ọnụ, injections, wdg. Tụkwasị na nke a, a pụkwara iji HPMC kwadebe emulsions, gels na foams, wdg, na-egosi. ike ya na ụlọ ọrụ ọgwụ.
8. Ọnụ ala
E jiri ya tụnyere ihe ndị ọzọ polymer, HPMC nwere ọnụ ahịa mmepụta dị ala, yana ihe anụ ahụ na kemịkal ya nwere ike gbanwee site n'ịgbanwe ogo nke nnọchi nke otu hydroxyl. Ya mere, ngwa nke HPMC na ụlọ ọrụ ọgwụ ọ bụghị nanị na-eme ka arụmọrụ nke ngwaahịa ahụ dịkwuo mma, kamakwa na-ebelata ọnụ ahịa mmepụta.
Ngwa sara mbara nke HPMC na ụlọ ọrụ ọgwụ bụ nsonaazụ nke ọtụtụ ihe ndị magburu onwe ya. Ma n'ịkwalite nkwụsi ike na bioavailability nke ọgwụ ma ọ bụ na-emeziwanye njirimara anụ ahụ nke nkwadebe, HPMC egosila uru dị ukwuu. Site na mmepe nke teknụzụ ọgwụ, atụmanya ngwa nke HPMC ka sara mbara, a na-atụkwa anya na ọ ga-ekere òkè dị ukwuu na mmepe na mmepụta ọgwụ ọhụrụ.
Oge nzipu: Sep-26-2024