Hydroxypropyl Cellulose (HPC) bụ excipient a na-ejikarị n'ọhịa ọgwụ nwere ọtụtụ ihe arụrụ arụ. A na-ejikarị ya na nkwadebe siri ike dị ka mbadamba nkume na capsules. Dị ka ihe na-emepụta cellulose semi-synthetic, a na-eme HPC site n'iwebata otu hydroxypropyl n'ime usoro ihe omimi nke cellulose, nke na-enye ya ezigbo solubility, adhesion and film-forming properties, na-eme ka ọ dị iche iche na nhazi mbadamba.
1. Thickers na Binders
HPC, dị ka a thickener na ihe nkedo, nwere ike inyere irighiri njikọ na-etolite n'oge mmiri granulation usoro nke mbadamba mmepụta. Ọ nwere ike adhesion na ike agbaso ezi ntụ ntụ ahụ ọnụ site na mmiri granulation na-etolite ahụ na ezi flowability na compressibility. Ihe ndị a dị mfe ịmepụta ma nwee ezigbo mkpakọ n'oge tableting, na-akpata mbadamba nkume dị elu. N'ime usoro nkwadebe mbadamba nkume, mgbakwunye nke ihe nkedo nwere ike hụ na ike siri ike, iguzogide nchikota na obere brittleness nke mbadamba nkume.
2. Ndị ọrụ mwepụta a na-achịkwa
Mmetụta ntọhapụ a na-achịkwa nke HPC na mbadamba nkume bụ otu n'ime ngwa ya kachasị mkpa. N'ihi ọzịza ya na viscosity Njirimara na mmiri, HPC nwere ike ịmepụta ihe nkiri hydration n'elu mbadamba nkume, na-amachi ntọhapụ nke ọgwụ ọjọọ, si otú ahụ nweta mmetụta nke igbu oge ntọhapụ ọgwụ. Na mbadamba mbadamba a na-achịkwa, HPC nwere ike ịhazigharị ọnụego ntọhapụ ọgwụ nke ọma site n'ịgbanwe nha molekụla ya na ego mgbakwunye ya, si otú a na-agbatị ogologo oge nke ọgwụ ahụ, na-ebelata oge nchịkwa ọgwụ, na imeziwanye nnabata onye ọrịa. Igwe mmiri hydration ya na-eji nwayọọ nwayọọ na-agbaze ka oge na-aga, ọnụego ntọhapụ ọgwụ na-adịkwa adịgide adịgide, na-eme ka ọ nwee atụmanya ngwa dị mma na mbadamba ihe ntọhapụ.
3. Onye na-emepụta ihe nkiri
Ihe ndị na-emepụta ihe nkiri HPC na-eme ka a na-eji ya eme ihe na mbadamba mbadamba, karịsịa ihe mkpuchi mmiri na-agbaze. Ikpuchi elu mbadamba nkume na ihe nkiri HPC nwere ike ịmepụta oyi akwa nchebe dị mkpa ma dị oke, nke nwere ike ọ bụghị nanị na-ekpuchi obi ilu nke ọgwụ ahụ ma melite uto, kamakwa chebe ọgwụ ahụ ma mee ka nkwụsi ike nke ọgwụ ahụ dịkwuo elu. N'ihi na HPC nwere ezigbo nghọta na mgbanwe, ihe nkiri ọ na-emepụta bụ otu na nke dị nro, na-enwekwa mmetụta dị nta na ọdịdị nke mbadamba. Na mgbakwunye, ihe nkiri HPC nwere ezigbo solubility na tract gastrointestinal na agaghị enwe mmetụta ọjọọ na bioavailability nke ọgwụ ahụ.
4. Stabilizer
Mmetụta nchebe nke HPC dịkwa oke mkpa na ntinye nke mbadamba nkume, karịsịa maka ọgwụ ndị ahụ na-emetụ ọkụ na iru mmiri. HPC nwere ike kewapụ mmetụta nke ikuku na mmiri nke ọma, ma gbochie ọgwụ ahụ ka ọ ghara imebi ma ọ bụ oxidative inactivation n'ihi mmiri. Karịsịa mgbe a na-akwadebe mkpuchi mbadamba nkume na ihe ndị na-edozi ahụ, nkwụsi ike na inertness kemịkalụ nke HPC na-egbochi ya imeghachi omume na ihe ndị na-emepụta ọgwụ na-arụ ọrụ, si otú ahụ na-eme ka nkwụsi ike na ndụ ndụ nke ọgwụ ahụ dị.
5. Na-agbasa
Ọ bụ ezie na a na-ejikarị HPC dị ka ihe ntọhapụ a na-achịkwa, enwere ike iji ya dị ka ihe na-agbasa na ụfọdụ mbadamba mbadamba ngwa ngwa. HPC nwere obere viscosity nwere ike ịgbaze ngwa ngwa ma zaa mgbe emechara ya na mmiri, na-eme ka mbadamba mbadamba ngwa ngwa gbasaa, si otú ahụ na-akwalite mgbasa na nnabata nke ọgwụ ahụ na eriri afọ. Ngwa a dabara adaba maka ọgwụ ụfọdụ chọrọ ka ọ rụọ ọrụ ngwa ngwa. HPC nwere ike nweta njirimara disintegration dị iche iche n'ụdị mbadamba nkume dị iche iche site n'ịgbanwe ịdị arọ ya, ego mgbakwunye na ihe ndị ọzọ.
6. Ngwa na mbadamba nkume na-etisa ọnụ
Mmiri solubility na viscosity nke HPC na-egosikwa mmetụta dị mma na mbadamba ụrọ na-etisa (ODT). N'ime mbadamba nkume a, HPC nwere ike ịkwalite ọnụego mgbasa nke mbadamba nkume n'ime oghere ọnụ, na-eme ka ọ dịrị ndị ọrịa mfe, karịsịa ndị agadi ma ọ bụ ụmụaka, ilo. Mmiri mmiri nke HPC na-eme ka ọ gbazee ma gbasaa n'ime obere oge, ebe viscosity ya na-eme ka ike nhazi nke mbadamba nkume ma gbochie ya imebi n'oge mmepụta na nchekwa.
7. Mmekọrịta na ndị ọzọ excipients
HPC nwekwara ezigbo ihe ndakọrịta nke mbadamba mbadamba ma nwee ike imekọrịta ya na ihe mgbakwunye ndị ọzọ (dịka microcrystalline cellulose, carboxymethyl cellulose, wdg) iji kwalite arụmọrụ nke mbadamba. Dịka ọmụmaatụ, mgbe ejikọtara ya na microcrystalline cellulose, HPC nwere ike imeziwanye mmiri na ịdị n'otu nke mbadamba nkume mgbe ị na-ahụ ike nke mbadamba nkume ahụ; mgbe ejiri ya na nrapado ndị ọzọ, ọ nwere ike ime ka adhesion nke mbadamba nkume dịkwuo elu, meziwanye àgwà granulation na mkpakọ ịkpụzi mmetụta.
8. Ihe na-emetụta ihe na njedebe
Ọ bụ ezie na HPC nwere ọtụtụ uru na mbadamba nkume, ya ojiji mmetụta na-emetụta ọtụtụ ihe, dị ka molekụla arọ, ịta, iru mmiri, wdg The ibu na molekụla arọ nke HPC, na elu nke viscosity, na ike ike ịchịkwa ọnụego ntọhapụ ọgwụ; n'otu oge ahụ, oke iru mmiri gburugburu ebe obibi nwere ike ime ka mbadamba nkume ahụ banye mmiri, na-emetụta nkwụsi ike ya. Ya mere, mgbe ị na-eji HPC, ọ dị mkpa iji ezi uche họrọ parampat kwesịrị ekwesị iji hụ na mmetụta kachasị mma na nhazi mbadamba.
Hydroxypropyl cellulose nwere ọtụtụ ọrụ n'ụdị mbadamba mbadamba, gụnyere thickener, ihe nkedo, onye na-ahụ maka mwepụta a na-achịkwa, ihe nkiri mbụ, stabilizer na disintegrant, nke nwere ike melite ogo mbadamba na arụmọrụ ntọhapụ ọgwụ. Dị ka ụfọdụ ọgwụ Njirimara na mmepụta chọrọ, dị iche iche molekụla arọ na dosages nke HPC nwere ike flexibly mezie viscosity, disintegration na ntọhapụ ọnụego nke mbadamba, na-eme ka ọ dị mkpa ngwa uru na ụlọ ọrụ ọgwụ.
Oge nzipu: Nov-04-2024