Hydroxypropyl methyl cellulose HPMC bụ na-abụghị ionic cellulose weere ether dị iche iche na ionic methyl carboxymethyl cellulose weere ether, ọ dịghị emeghachi omume na arọ ọla. Otu oxygen radicals n'ihi hydroxypropyl methyl cellulose ọdịnaya na dị iche iche nkezi nke hydroxypropyl ọdịnaya na viscosity, ghọrọ iche iche na arụmọrụ, dị ka ihe atụ, elu metoxyl ọdịnaya na obere ọdịnaya nke hydroxypropyl iche, ya arụmọrụ dị nso na methyl cellulose na ala methoxyl. ọdịnaya na ọdịnaya dị elu nke ụdị hydroxypropyl, yana arụmọrụ ya dị nso na hydroxypropyl methyl cellulose na-emepụta. Ma na nke ọ bụla dị iche iche, ọ bụ ezie na ọ bụ naanị nwere obere hydroxypropyl ma ọ bụ obere methoxy, solubility na organic solvents ma ọ bụ flocculation okpomọkụ na aqueous ngwọta, e nwere nnukwu ọdịiche.
1, hydroxypropyl methyl cellulose solubility
Hydroxypropyl methyl cellulose na mmiri solubility nke hydroxypropyl methyl cellulose bụ n'ezie a ụdị propylene oxide (methyl oxypropyl mgbanaka) gbanwetụrụ methyl cellulose, n'ihi ya, ọ ka nwere yiri methyl cellulose mmiri oyi soluble na mmiri ọkụ insoluble e ji mara. Otú ọ dị, okpomọkụ gelation nke hydroxy propyl gbanwetụrụ dị elu karịa nke methyl cellulose na mmiri ọkụ. Dịka ọmụmaatụ, viscosity nke hydroxypropyl methylcellulose aqueous solution na 2% methoxy ọdịnaya DS=0.73 na hydroxypropyl ọdịnaya MS=0.46 bụ 500mpa na 20℃. Gel okpomọkụ nke ngwaahịa S dị nso 100 ℃, ebe nke methyl cellulose nke otu okpomọkụ bụ nanị banyere 55 ℃. Dị ka ya solubility na mmiri, na-ukwuu mma ka ihe atụ, mgbe etipịa hydroxypropyl methylcellulose (ọka udi 0.2 ~ 0.5mm na 20℃ 4% aqueous viscosity nke 2pA? S ngwaahịa nwere ike mfe etisasịwo na mmiri na-enweghị jụrụ na ụlọ okpomọkụ. .
(2). DS = 0.2 ~ 1.0, High viscosity hydroxypropyl methyl cellulose na ngụkọta nnọchi ogo n'elu 1.8 bụ soluble na anhydrous methanol na ethanol ngwọta, na nwere thermoplastic na mmiri solubility. Ọ na-agbazekwa na hydrocarbons chlorinated dị ka dichloromethane na trichloromethane, na ihe mgbaze organic dị ka acetone, mmanya isopropyl, na mmanya diacetone. Ya solubility na organic solvents dị elu karịa mmiri solubility.
2, hydroxypropyl methyl cellulose viscosity nke ihe na-emetụta
Hydroxypropyl methylcellulose viscosity ihe hydroxypropyl methylcellulose ọkọlọtọ viscosity mkpebi siri ike, na ndị ọzọ cellulose ether bụ otu, bụ na 20℃ na 2% aqueous ngwọta dị ka ọkọlọtọ mkpebi siri ike. Viscosity nke otu ngwaahịa ahụ, yana mmụba nke itinye uche na mmụba, otu ntinye nke ngwaahịa dị arọ dị iche iche, ịdị arọ molecular nke ngwaahịa ahụ bụ nnukwu viscosity. Mmekọrịta ya na okpomọkụ yiri nke methyl cellulose. Mgbe okpomọkụ na-ebili, viscosity na-amalite ibelata, ma mgbe ọ ruru ụfọdụ okpomọkụ, viscosity na-ebili na mberede na gelation na-eme. Okpomọkụ gelation nke ngwaahịa ndị nwere obere viscosity dị elu karịa nke ngwaahịa nwere nnukwu viscosity. Ọkwa nke ebe gel ya, na mgbakwunye na viscosity dị elu na nke dị ala nke ether, kamakwa yana ether methoxy na hydroxypropyl otu mejupụtara ratio na ngụkọta ogo nnọchi. Ọ ga-kwuru na hydroxypropyl methylcellulose bụkwa pseudoplastic; ngwọta ya kwụsiri ike mgbe echekwara ya na ụlọ okpomọkụ ma ọ dịghị egosi mmebi ọ bụla nke viscosity ma e wezụga n'ihi na enwere ike imebi enzymatic.
3, hydroxypropyl methyl cellulose acid na alkaline iguzogide
Hydroxypropyl methylcellulose acid alkali hydroxypropyl methylcellulose acid na alkali, n'ozuzu kwụsiri ike, na ph PH2 ~ 12 nso adịghị emetụta, ọ nwere ike idi a ụfọdụ ego nke ìhè acid, dị ka formic acid, acetic acid, citric acid, succinic acid, phosphoric. acid, boric acid, wdg. Ma acid a na-etinye uche nwere mmetụta nke ibelata viscosity. Alkali dị ka soda caustic, potassium caustic na mmiri lime enweghị mmetụta na ya, ma mmetụta nke ịba ụba viscosity nke ngwọta ga-eji nwayọọ nwayọọ na-ebelata n'ọdịnihu.
4, hydroxypropyl methyl cellulose nwere ike ịgwakọta
Hydroxypropyl methyl cellulose ngwọta nwere ike ịgwakọta na mmiri-soluble polymer ogige, na-aghọ a edo transperent ngwọta na elu viscosity. Ndị a dị elu molekụla ogige bụ polyethylene glycol, polyvinyl acetate, polysilicon, polymethyl vinyl siloxane na hydroxyethyl cellulose na methyl cellulose, wdg Natural polymer ogige dị ka chịngọm Arabic, igurube agwa chịngọm, ogwu osisi chịngọm na na nwekwara ezigbo ngwakọta na ya. ngwọta. Hydroxypropyl methyl cellulose nwekwara ike jikọta ya na stearic acid ma ọ bụ palmitic acid mannitol ester ma ọ bụ sorbitol ester, kamakwa na glycerol, sorbitol na mannitol, a pụrụ iji ogige ndị a dị ka hydroxypropyl methyl cellulose plasticizer.
5, hydroxypropyl methyl cellulose insoluble mmiri soluble
Hydroxypropyl methyl cellulose insoluble mmiri-soluble cellulose ether, nwere ike ịbụ n'elu cross-njikọ na aldehydes, na-eme ka ndị a mmiri-soluble ether precipitated na ngwọta, ghọọ insoluble na mmiri. Ma mee ka hydroxypropyl methylcellulose insoluble aldehyde, formaldehyde, glioxal, succinaldehyde, dialdehyde, wdg, ojiji nke formaldehyde kwesịrị ilebara anya pụrụ iche na PH uru nke ngwọta, nke glyoxal mmeghachi omume ngwa ngwa, ya mere na mmepụta mmepụta ihe na-ejikarị glioxal dị ka obe. -njikọ gị n'ụlọnga. Usoro ọgwụgwọ ụdị crosslinking a na ngwọta bụ 0.2% ~ 10% nke ether mass, nke kachasị mma bụ 7% ~ 10%, dị ka iji glioxal na 3.3% ~ 6% bụ ihe kwesịrị ekwesị. The izugbe ọgwụgwọ okpomọkụ bụ 0 ~ 30 ℃, oge bụ 1 ~ 120min. A ghaghị ime mmeghachi omume na-ejikọta ya n'okpuru ọnọdụ acidic. N'ozuzu, inorganic acid siri ike ma ọ bụ organic carboxylic acid na-agbakwunye na ngwọta iji dozie PH nke ngwọta na ihe dịka 2 ~ 6, ọkacha mma n'etiti 4 ~ 6, mgbe ahụ, a na-agbakwunye aldehydes maka mmeghachi omume na-ejikọta ya. Acids eji eme ihe bụ hydrochloric acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, hydroxy acetic acid, succinic acid ma ọ bụ citric acid, n'ime nke formic acid ma ọ bụ acetic acid kacha mma, ebe formic acid kacha mma. Acids na aldehydes nwekwara ike ịgbakwunye n'otu oge iji mee ka ihe ngwọta na-agafe na oke PH chọrọ. A na-ejikarị mmeghachi omume a eme ihe na usoro ikpeazụ nke cellulose ether nkwadebe usoro, nke mere na cellulose ether adịghị agbaze, dị mfe iji 20 ~ 25 ℃ mmiri na-asa na ọcha. Mgbe a na-eji ngwaahịa ahụ eme ihe, enwere ike ịgbakwunye ihe ndị na-edozi ahụ na ngwọta nke ngwaahịa ahụ iji dozie PH nke ngwọta ka ọ bụrụ alkaline, na ngwaahịa ahụ na-agbaze ngwa ngwa na ngwọta. A pụkwara iji usoro a mee ihe mgbe a na-eji ngwọta cellulose ether mee ihe nkiri na mgbe ahụ, a na-emeso ihe nkiri ahụ iji mee ihe nkiri na-adịghị edozi.
6, hydroxypropyl methyl cellulose mgbochi enzyme
Hydroxypropyl methyl cellulose enzyme eguzogide cellulose mmepụta na tiori, dị ka onye ọ bụla anhydroglucose iche iche dị ka e nwere a siri ike Nchikota nke dochie ìgwè, ozize nke microorganisms bụ obere susceptible ka ọrịa, ma n'ezie okokụre ngwaahịa iji dochie uru karịa 1, Sitekwa nbibi nke enzyme, nke a bụ nkọwa nke otu ọ bụla n'ime usoro ngbanwe nke cellulose abụghị otu, Microorganisms nwere ike imebi nso. Otu glucose akpọnwụ akpọnwụ na-edochighị anya na-etolite shuga, nke ụmụ nje nwere ike ịmịnye ya dị ka nri. Ya mere, ọ bụrụ na etherification ngbanwe nke cellulose na-abawanye, a ga-eme ka nguzogide cellulose ether na-emebi emebi nke enzymatic. A na-akọ na n'okpuru ọnọdụ a na-achịkwa, viscosity fọdụrụnụ nke hydroxypropyl methyl cellulose (DS=1.9), methyl cellulose (DS=1.83), methyl cellulose (DS=1.66), na hydroxyethyl cellulose (1.7%) bụ 13.2%, 7.3% 3.8% na 1.7% n'otu n'otu. Hydroxypropyl methyl cellulose nwere ike mgbochi enzyme ike. Ya mere hydroxypropyl methylcellulose magburu onwe mgbochi enzyme, jikọtara ya na mma dispersion, ndim na film guzobe, etinyere na emulsion coatings, wdg, n'ozuzu adịghị mkpa ịgbakwunye preservatives. Otú ọ dị, iji gbochie nchekwa ogologo oge nke ngwọta ma ọ bụ mmetọ nwere ike site n'èzí, a pụrụ ịgbakwunye ihe nchekwa, nke nhọrọ ya nwere ike ikpebi dịka ihe ikpeazụ chọrọ nke ngwọta ahụ. Phenylmercuric acetate na manganese fluosilicate bụ ihe nchekwa dị irè, mana ha na-egbu egbu, a ga-ejikwa nlezianya mee ya. N'ozuzu, 1 ~ 5mg phenylmercuric acetate nwere ike ịgbakwunye na liter nke ngwọta ọ bụla.
7, hydroxypropyl methyl cellulose membrane arụmọrụ
Hydroxypropyl methyl cellulose film arụmọrụ nke hydroxypropyl methyl cellulose nwere magburu onwe film, ya aqueous ngwọta ma ọ bụ organic mgbaze ngwọta, ntekwasa na iko efere, mgbe ihicha na-aghọ enweghị colorless, transperent na siri ike film. Ọ nwere ezigbo nguzogide mmiri ma na-anọgidesi ike na oke okpomọkụ. Dị ka mgbakwunye nke hygroscopic plasticizer, nwere ike ịkwalite elongation na mgbanwe ya, iji meziwanye mgbanwe, glycerol na sorbitol na plasticizer ndị ọzọ bụ ihe kacha mma. Ngwọta ngwọta zuru oke bụ 2% ~ 3%, usoro ọgwụgwọ plasticizer bụ 10% ~ 20% nke cellulose ether. Ọ bụrụ na ọdịnaya nke plasticizer na-apụ apụ, ihe nhụsianya nke ụkọ mmiri colloid nwere ike ime na oke iru mmiri. Ike ike nke ihe nkiri ahụ agbakwunyere plasticizer dị nnọọ ukwuu karịa nke a na-agbakwunyeghị, ma na-abawanye na mmụba nke ọnụ ọgụgụ agbakwunyere, n'ihi na hygroscopicity nke ihe nkiri ahụ na-abawanye site na mmụba nke plasticizer.
Oge nzipu: Sep-08-2022