Hydroxypropyl Methylcellulose (HPMC) bụ polymer vasatail nke na-achọta ngwa dị ukwuu n'ofe ụlọ ọrụ dị iche iche, gụnyere ọgwụ, nri, ihe owuwu, na ịchọ mma. Ngwongwo ya pụrụ iche na-eme ka ọ bụrụ ihe dị mkpa na usoro chọrọ ngbanwe viscosity, nhazi ihe nkiri, njide, na nkwalite nkwụsi ike. Ịghọta ihe mejupụtara, usoro nrụpụta, akụrụngwa na ngwa nke HPMC dị oke mkpa maka iji ya rụọ ọrụ nke ọma.
1.Composition nke HPMC
HPMC bụ polymer synthetic nke na-enweta site na cellulose, polysaccharide na-emekarị nke a na-ahụ na mgbidi cell nke osisi. Usoro mmepụta ihe gụnyere ịgwọ cellulose na alkali iji mepụta cellulose alkali, na-esote etherification na propylene oxide na methyl chloride. Mgbanwe kemịkalụ a na-ebute iwebata hydroxypropyl na methoxy n'ime ọkpụkpụ azụ cellulose, na-enye HPMC.
Ogo nke nnọchi (DS) nke hydroxypropyl na methoxy otu na-ekpebi njirimara nke HPMC, gụnyere solubility, gelation, na njirimara imepụta ihe nkiri. Na-emekarị, akara ule HPMC nwere ụkpụrụ DS dị elu na-egosipụta mmụba solubility na mmiri yana nkwalite ike gelation.
2. Njirimara nke HPMC
Mmiri Solubility: HPMC bụ soluble na mmiri oyi, na-akpụ ngwọta doro anya, viscous. Enwere ike ịhazi solubility ahụ site n'ịgbanwe ogo ngbanwe, ịdị arọ molekụla, na okpomọkụ.
Nhazi ihe nkiri: HPMC nwere ike ịmepụta ihe nkiri na-agbanwe agbanwe na nke doro anya mgbe ihicha. Ihe nkiri ndị a nwere ihe mgbochi dị mma, na-eme ka ha dị mma maka mkpuchi mkpuchi na ụlọ ọrụ ọgwụ na nri.
Mgbanwe nke viscosity: HPMC na-egosipụta omume pseudoplastic, ebe viscosity ya na-ebelata na ọnụ ọgụgụ shear na-abawanye. A na-eji ihe onwunwe a n'ụdị dị iche iche iji chịkwaa omume na-asọpụta na njirimara rheological.
Thermal Stability: HPMC na-egosipụta nkwụsi ike n'elu oke okpomọkụ, na-eme ka ọ dị mma maka ngwa ndị chọrọ nhazi okpomọkụ ma ọ bụ ikpughe na okpomọkụ dị elu.
Inertness kemịkalụ: HPMC bụ kemịkalụ inert, dakọtara na ọtụtụ ihe mgbakwunye, ihe mgbakwunye na ihe ndị na-arụ ọrụ nke a na-ejikarị na usoro ọgwụ na nri.
3.Synthesis nke HPMC
Ngwakọta nke HPMC gụnyere ọtụtụ usoro:
Ọgwụgwọ Alkali: A na-emeso cellulose na alkali, dị ka sodium hydroxide, iji mepụta cellulose alkali.
Etherification: Alkali cellulose na-emeghachi omume na propylene oxide iji webata otu hydroxypropyl n'ime ọkpụkpụ azụ cellulose.
Methylation: A na-agwọkwa cellulose hydroxypropylated na methyl chloride iji webata otu methoxy, na-enye HPMC.
Ịdị ọcha: A na-asachapụ HPMC nke a na-emepụta iji wepụ ngwaahịa na adịghị ọcha, na-ahụ na ọ dị mma na nkwụsi ike nke ngwaahịa.
4. Ngwa nke HPMC
Ụlọ ọrụ na-emepụta ọgwụ: A na-eji HPMC eme ihe n'ọtụtụ ebe dị ka ihe na-emepụta ọgwụ na mbadamba mbadamba, ebe ọ na-eje ozi dị ka onye na-ekekọta, ihe na-ekpochapụ, na onye na-ahapụ ya. A na-ejikwa ya na ngwọta anya, ude dị n'elu, na nkwusioru ọnụ n'ihi ihe ndị na-emepụta ihe na ihe ndị na-emepụta mucoadhesive.
Ụlọ ọrụ nri: N'ụlọ ọrụ nri, HPMC na-eje ozi dị ka onye na-agbapụta, stabilizer, na emulsifier na ngwaahịa dị iche iche, gụnyere sauces, uwe, na mmiri ara ehi ndị ọzọ. A na-ejikwa ya n'ime achịcha na-enweghị gluten dị ka ihe na-emepụta texturize na ihe na-eme ka mmiri na-ejide mmiri.
Ụlọ ọrụ ihe owuwu: HPMC bụ ihe mgbakwunye dị mkpa na ngwa ngwa simenti, plasta, na nrapado tile. Ọ na-eme ka arụ ọrụ dịkwuo mma, njide mmiri, na adhesion, na-enye aka n'ịrụ ọrụ na ịdịte aka nke ihe owuwu.
Ngwaahịa Nlekọta Onwe Onye: Agbakwunyere HPMC n'ime ihe ịchọ mma, ngwaahịa nlekọta anụ ahụ, na usoro nlekọta ntutu maka imepụta ihe nkiri, ịgbatị na ihe emulsifying. Ọ na-enye udidi a na-achọsi ike, nkwụsi ike, na njirimara mmetụta na lotions, creams, na gels.
Mkpuchi na nkwakọ ngwaahịa: A na-etinye ihe mkpuchi sitere na HPMC na mbadamba ọgwụ na capsules iji meziwanye ike ilo, ụtọ nkpuchi, ma nye nchebe mmiri. A na-ejikwa ihe nkiri HPMC na nkwakọ ngwaahịa nri dị ka mkpuchi oriri ma ọ bụ ihe mgbochi megide mmiri na ikuku oxygen.
Hydroxypropyl Methylcellulose (HPMC) bụ polymer na-arụ ọrụ dị iche iche nwere ngwa dị iche iche n'ofe ụlọ ọrụ. Ngwakọta ya pụrụ iche, gụnyere mmiri solubility, nhazi ihe nkiri, mgbanwe viscosity, na inertness kemịkalụ, na-eme ka ọ dị mkpa na ọgwụ, nri, ihe owuwu, na ngwaahịa nlekọta onwe onye. Ịghọta ihe mejupụtara, njikọ, akụrụngwa na ngwa nke HPMC dị mkpa maka ndị na-emepụta ihe na ndị na-emepụta ihe na-achọ iji nweta uru ya na mmepe ngwaahịa na mmepụta ihe ọhụrụ.
Ihe HPMC pụtara dabere na ngbanwe ya, ọrụ ya, yana ntinye aka n'ịkwalite arụmọrụ, nkwụsi ike na njirimara mmetụta nke ngwaahịa dị iche iche na mpaghara dị iche iche, na-eme ka ọ bụrụ ihe bara uru na nhazi na ngwa ọgbara ọhụrụ.
Oge nzipu: Feb-29-2024