Hypromellose, nke a makwaara dị ka hydroxypropyl methylcellulose (HPMC), bụ polymer semi-synthetic vasatail ewepụtara na cellulose. N'ihi kemịkalụ ya pụrụ iche na nke anụ ahụ, a na-ejikarị HPMC eme ihe dị ka thickener, stabilizer na nrapado na ụlọ ọrụ ọgwụ, nri na nlekọta onwe onye. N'isiokwu a, anyị na-atụle kemistri nke HPMC na ngwa ha dị mkpa.
1. Solubility
Otu n'ime ihe kacha mkpa kemịkalụ nke HPMC bụ ya solubility. HPMC bụ soluble na mmiri na ọtụtụ organic solvents, na-eme ka ọ bụrụ ezigbo akụrụngwa maka ọgwụ nnyefe usoro na ndị ọzọ ngwa na-achọ mgbasa. Agbanyeghị, solubility nke HPMC na-ekpebi nke ukwuu site na ogo nnọchi ya (DS), nke na-ekpebi ọnụọgụ hydroxypropyl na methyl dị na yinye polymer. Ndị HPMC nwere DS dị elu nwere solubility dị ala n'ihi mmụba intermolecular mmekọrịta.
2. Rheology
Ihe ọzọ dị mkpa kemịkalụ nke HPMC bụ omume rheological ya. HPMC si ike na-etolite a gel-dị ka netwọk n'elu hydration nwere ike jikwaa viscosity na eruba àgwà nke formulations. HPMC na-egosipụtakwa omume na-erugharị na-abụghị Newtonian, nke pụtara na viscosity ya na-agbanwe dịka ọnụego shear etinyere n'ọrụ. Enwere ike ịchịkwa ihe onwunwe a site n'ịgbanwe ntinye nke HPMC na DS na nhazi.
3. Nhazi ihe nkiri
A na-ejikwa HPMC n'ọtụtụ ebe dị ka ihe nkiri mbụ n'ihi ike ọ nwere ịmepụta ihe nkiri otu mgbe etinyere ya na mkpụrụ. Ihe na-emepụta ihe nkiri nke HPMC na-adabere na DS ya, viscosity na ọnụnọ nke plasticizers, nke nwere ike imeziwanye mgbanwe na mgbanwe nke ihe nkiri ahụ. A na-ejikarị ihe nkiri emere na HPMC na nnyefe ọgwụ n'ihi na ha na-ekwe ka mwepụta nke ihe ndị na-arụ ọrụ na-achịkwa.
4. Ndakọrịta
HPMC bụ ihe enyemaka dakọtara nke ukwuu ma enwere ike iji ya mee ihe n'ụdị dị iche iche. Ọ dakọtara na ọtụtụ ihe ndị na-emepụta ọgwụ, gụnyere ihe ndị na-emepụta ọgwụ na-arụsi ọrụ ike (API) na ihe ndị ọzọ na-emepụta ọgwụ na-ejikarị eme ihe n'usoro ọgwụ. HPMC dakọtara na ọtụtụ ihe oriri, na-eme ka ọ bụrụ nhọrọ a ma ama maka ngwa nri.
5. Chemical kwụsie ike
HPMC bụ polymer kwụsiri ike nke na-eguzogide hydrolysis na mmeghachi omume kemịkalụ ndị ọzọ. Nkwụsi ike a na-eme ka ọ bụrụ ihe dị mma maka usoro nnyefe ọgwụ dịka ọ na-echebe ihe na-arụ ọrụ site na mmebi ma na-abawanye bioavailability ya. Agbanyeghị, nkwụsi ike kemịkalụ nke HPMC nwere ike imetụta oke okpomọkụ, oke iru mmiri, na ụfọdụ ihe mgbaze, nke nwere ike ime ka polymer mebie ma belata ịdị irè ya na usoro.
6. Biocompatibility
N'ikpeazụ, HPMC bụ polymer na-arụkọ ọrụ nke ọma nke dị mma maka iji ọgwụ na ngwaahịa nlekọta onwe onye. Ọ bụ ihe na-adịghị egbu egbu, na-abụghị immunogen na biodegradable, na-eme ka ọ dị mma maka nhazi nke chọrọ obere nsị na nchekwa kachasị.
Na nchịkọta, HPMC hypromellose bụ polymer multifunctional nwere ọtụtụ ihe dị mkpa kemịkalụ, gụnyere solubility, rheology, ihe na-emepụta ihe nkiri, ndakọrịta, nkwụsi ike kemịkalụ, na biocompatibility. Ngwongwo ndị a na-eme ka ọ bụrụ ihe dị mma maka usoro nnyefe ọgwụ na ngwa ndị ọzọ na ụlọ ọrụ nri na nlekọta onwe onye. Ka nyocha na-aga n'ihu na-agbasawanye nghọta anyị banyere HPMC, ihe onwunwe ha pụrụ iche nwere ike ịhụ ngwa ndị sara mbara n'ọdịnihu.
Oge nzipu: Jul-28-2023