Hydroxypropyl Methylcellulose (HPMC) bụ ihe dị mkpa cellulose ether ewepụtara nke ejirila n'ọtụtụ ebe mmepụta ihe n'ihi njirimara anụ ahụ na kemịkal pụrụ iche. Njirimara viscosity ya bụ otu n'ime ihe kachasị mkpa nke HPMC, na-emetụta arụmọrụ ya na ngwa dị iche iche.
1. Ihe ndị bụ isi nke HPMC
HPMC bụ nonionic cellulose ether enwetara site na dochie akụkụ nke hydroxyl otu (-OH) na cellulose molekul na methoxy otu (-OCH3) na hydroxypropyl otu (-OCH2CH (OH) CH3). Ọ nwere ezigbo solubility na mmiri na ụfọdụ ihe mgbaze organic, na-akpụ ngwọta colloidal transperent. A na-ekpebi viscosity nke HPMC tumadi site na ibu molekụla ya, ogo nnọchi anya (DS, Degree of Substitution) na nkesa nnọchi.
2. Mkpebi nke viscosity nke HPMC
A na-atụkarị viscosity nke ngwọta HPMC site na iji viscometer rotational ma ọ bụ viscometer capillary. Mgbe ị na-atụle, ọ dị mkpa ka e lebara anya na ntinye uche, okpomọkụ na nkwụsị nke ngwọta, n'ihi na ihe ndị a nwere ike imetụta uru viscosity nke ukwuu.
Ngwọta Ngwọta: The viscosity nke HPMC na-abawanye na mmụba nke ngwọta ntinye uche. Mgbe ntinye nke ngwọta HPMC dị ala, mmekọrịta dị n'etiti ụmụ irighiri ihe na-esiwanye ike ma viscosity dị ala. Ka ntinye uche na-abawanye, njikọ na mmekọrịta dị n'etiti ụmụ irighiri ihe na-abawanye, na-eme ka mmụba dị ukwuu na viscosity.
Okpomọkụ: The viscosity nke HPMC ngwọta na-enwe mmetụta nke ukwuu okpomọkụ. N'ozuzu, ka okpomọkụ na-abawanye, viscosity nke HPMC ngwọta ga-ebelata. Nke a bụ n'ihi mmụba okpomọkụ na-eduga n'ịbawanye mmegharị molekụla na mmekọrịta intermolecular adịghị ike. Ekwesiri ighota na HPMC nwere ogo di iche iche nke nnochi anya na ibu molecular nwere mmetụta di iche iche na onodu okpomọkụ.
Ọnụ ego shear: Ihe ngwọta HPMC na-egosipụta àgwà pseudoplastic (shiee thinning), ya bụ, viscosity dị elu na ọnụ ọgụgụ dị ala nke shear ma na-ebelata na ọnụ ọgụgụ dị elu. Omume a bụ n'ihi ike ịkwa akwa na-edozi agbụ mkpụrụ ndụ n'akụkụ ntụzịaka shear, si otú a na-ebelata njikọ na mmekọrịta dị n'etiti ụmụ irighiri ihe.
3. Ihe na-emetụta HPMC viscosity
Arọ molecular: Arọ molikula nke HPMC bụ otu n'ime isi ihe na-ekpebi viscosity ya. N'ikwu okwu n'ozuzu, ka ibu molekụla buru ibu, ka viscosity nke ngwọta dị elu. Nke a bụ n'ihi na ụmụ irighiri ihe nke HPMC nwere ibu arọ molekụla dị elu na-enwekarị ike imepụta netwọkụ jikọtara ọnụ, si otú ahụ na-abawanye esemokwu dị n'ime nke ngwọta ahụ.
Ogo nke nnọchi na nkesa nnọchi: Ọnụọgụ na nkesa nke methoxy na hydroxypropyl nnọchi na HPMC na-emetụtakwa viscosity ya. N'ozuzu, ogo nke methoxy nnọchi (DS), na-ebelata viscosity nke HPMC, n'ihi na iwebata ihe nnọchi methoxy ga-ebelata ike njikọ hydrogen n'etiti ụmụ irighiri ihe. Iwebata ihe nnọchi hydroxypropyl ga-abawanye mmekọrịta intermolecular, si otú ahụ na-abawanye viscosity. Tụkwasị na nke ahụ, nkesa otu nke ihe ndị na-anọchi anya na-enyere aka ịmepụta usoro ngwọta kwụsiri ike ma mee ka viscosity nke ngwọta dịkwuo elu.
Uru pH nke ngwọta: Ọ bụ ezie na HPMC bụ polymer na-abụghị ionic na viscosity ya adịghị enwe mmetụta maka mgbanwe na uru pH nke ngwọta, oke pH (nke dị oke acidic ma ọ bụ alkaline) nwere ike ime ka mmebi nke usoro ihe omimi nke molekul. HPMC, si otú ahụ na-emetụta viscosity.
4. Ngwa ubi nke HPMC
N'ihi njirimara viscosity ya magburu onwe ya, a na-eji HPMC eme ihe n'ọtụtụ ebe:
Ihe owuwu ụlọ: N'ime ihe owuwu ụlọ, a na-eji HPMC eme ihe dị ka ihe na-ekpuchi mmiri na onye na-ejigide mmiri iji melite arụmọrụ ihe owuwu yana ịbawanye nkwụsị mgbape.
Ụlọ ọrụ na-emepụta ọgwụ: N'ime ụlọ ọrụ na-emepụta ọgwụ, a na-eji HPMC dị ka ihe nkwụnye maka mbadamba nkume, onye na-emepụta ihe nkiri maka capsules na onye na-ebu maka ọgwụ na-adịgide adịgide.
Ụlọ ọrụ nri: A na-eji HPMC eme ihe dị ka onye na-agba ume na stabilizer na ụlọ ọrụ nri maka mmepụta nke ice cream, jelii na ngwaahịa mmiri ara ehi.
Ngwaahịa kemịkalụ kwa ụbọchị: N'ime ngwaahịa kemịkalụ kwa ụbọchị, a na-eji HPMC eme ihe dị ka thickener na stabilizer maka imepụta ncha ntutu, gel ịsa ahụ, ntacha eze, wdg.
Njirimara viscosity nke HPMC bụ ihe ndabere maka arụmọrụ ya dị mma na ngwa dị iche iche. Site n'ịchịkwa ịdị arọ molekụla, ogo ngbanwe, na ọnọdụ ngwọta nke HPMC, enwere ike gbanwee viscosity ya iji gboo mkpa ngwa dị iche iche. N'ọdịnihu, n'ime omimi nnyocha na mmekọrịta dị n'etiti HPMC molekul Ọdịdị na viscosity ga-enyere aka ịzụlite HPMC ngwaahịa na mma arụmọrụ na n'ihu gbasaa ya ngwa ubi.
Oge nzipu: Jul-20-2024