Hydroxypropylmethylcellulose (HPMC) bụ polymer vasatail nke a na-ejikarị eme ihe na ụlọ ọrụ dị iche iche n'ihi njirimara ya pụrụ iche. Ngwakọta a bụ ihe sitere na cellulose, polymer eke dị na mgbidi cell osisi. Njikọ nke HPMC na-agụnye ịgwọ cellulose na propylene oxide iji webata otu hydroxypropyl yana yana methyl chloride iji webata otu methyl. Ihe na-esi na polymer pụta na-egosipụta ụdị anụ ahụ na kemịkal dị iche iche, na-eme ka ọ dị mma maka iji ọgwụ, ihe owuwu, nri na ụlọ ọrụ ndị ọzọ.
1.Chemical Ọdịdị na mejupụtara:
Hydroxypropyl methylcellulose bụ polymer synthetic ọkara nke nwere usoro kemịkalụ dị mgbagwoju anya. Ọkpụkpụ azụ nke polymer nwere cellulose, eriri ahịrị ahịrị nke molekul glucose jikọtara ya na njikọ β-1,4-glycosidic. A na-ewebata otu hydroxypropyl site na dochie otu hydroxyl (-OH) na otu propyl, na otu methyl na-ewebata n'otu ụzọ ahụ. Ogo nke nnọchi (DS) na-anọchi anya nkezi ọnụọgụ hydroxypropyl na methyl otu n'otu glucose ma na-emetụta solubility, viscosity, na thermal Njirimara nke polymer.
2. Solubility:
Otu n'ime ihe pụrụ iche nke HPMC bụ omume mgbasa ya. Ọ na-edozi ya na mmiri oyi na mmiri ọkụ, na-enye uru pụrụ iche na ngwa dị iche iche. Enwere ike idozi solubility site n'ịgbanwe ogo ngbanwe na ịdị arọ molecular nke polymer. Ngwongwo a na-eme HPMC bụrụ ezigbo onye ndoro-ndoro maka sistemụ nnyefe ọgwụ na-achịkwa, ebe ọnụego mgbasa na-arụ ọrụ dị mkpa na ntọhapụ ọgwụ.
3. Viscosity:
Hydroxypropyl methylcellulose dị n'ọtụtụ ọkwa viscosity dị iche iche, dabere na ihe ndị dị ka ịdị arọ molekụla, ogo ngbanwe, na ntinye ngwọta. The viscosity nke HPMC ngwọta na-enye ha ohere iji na ọtụtụ ulo oru ngwa, gụnyere pharmaceuticals, dị ka thickeners na mmiri mmiri dosage ụdị, na dị ka film-akpụ ihe maka coatings.
4. Ịrụ ihe nkiri:
Ikike imepụta ihe nkiri nke HPMC dị oke egwu na ngwa dị ka mkpuchi ọgwụ, ebe a na-eji ya na-enye oyi akwa mkpuchi iji kpuchie uto nke ọgwụ, na-achịkwa mwepụta ọgwụ, ma melite nkwụsi ike. Ihe nkiri HPMC doro anya ma na-agbanwe agbanwe, enwere ike ịhazi akụrụngwa ha site na ịhazigharị mkpokọta polymer, ịdị arọ molecular na ọdịnaya plasticizer.
5. Ọrụ okpomọkụ:
Hydroxypropyl methylcellulose na-egosiputa nkwụsi ike dị mma n'ime oke okpomọkụ. Ihe ndị dị ka ogo ngbanwe, ịdị arọ molekụla, na ọnụnọ nke plasticizers na-emetụta akụrụngwa okpomọkụ. Ngwongwo ndị a na-eme ka HPMC dabara maka ngwa ebe nkwụsi ike okpomọkụ dị oke egwu, dị ka nkwadebe nke usoro ọgwụ na-ekpo ọkụ na-ekpo ọkụ.
6. Nkwekọrịta dị ndụ:
Na mpaghara ọgwụ na biomedical, biocompatibility bụ ihe dị mkpa maka ihe eji eme ihe na usoro nnyefe ọgwụ. A na-ewerekarị Hydroxypropyl methylcellulose dị ka ọ dị mma ma nwee ezigbo bioocompatibility. A na-eji ya eme ihe n'ụdị usoro onunu ogwu, ngwọta anya na usoro nnyefe ọgwụ na-achịkwa.
7. Njide mmiri na ihe na-eme ka mmiri sie ike:
Ike HPMC idowe mmiri na itucha ihe ngwọta na-eme ka ọ baa uru n'ihe owuwu ihe dịka ngwaahịa simenti. N'ime ngwa ndị a, HPMC na-arụ ọrụ dị ka onye na-ejigide mmiri, na-emeziwanye usoro nhazi na igbochi ihicha ihe onwunwe. A na-ejikwa ihe ndị na-eme ka ahụ sie ike n'ụdị nri dị iche iche iji kwalite ọdịdị na mmetụta ọnụ.
8. nnyefe ọgwụ na-achịkwa achịkwa:
Otu n'ime ngwa dị mkpa nke hydroxypropyl methylcellulose bụ na nhazi usoro nnyefe ọgwụ na-achịkwa. Ihe ndị dị na polymer solubility, viscosity, na ihe ndị na-emepụta ihe nkiri na-akwado ntọhapụ nke ọgwụ na-achịkwa, na-eme ka nnyefe ọgwụ na-adịgide adịgide na ezubere iche. Nke a bara uru karịsịa maka imeziwanye nnabata onye ọrịa yana ibelata mmetụta ndị metụtara ntọhapụ ọgwụ ngwa ngwa.
9. Nkwụsi ike n'okpuru gburugburu pH dị iche iche:
HPMC na-egosipụta nkwụsi ike n'elu oke pH, na-eme ka ọ dabara maka nhazi nke chọrọ nkwụsi ike n'okpuru ọnọdụ acidic ma ọ bụ alkaline. Ihe onwunwe a bara uru na ọgwụ ọgwụ n'ihi na nhazi ọgwụ nwere ike izute gburugburu pH dị iche iche na eriri afọ.
10. Nrụpụta ọmụmụ:
Omume rheological nke ngwọta HPMC dị oké mkpa maka ngwa ebe ihe ndị na-asọpụta dị oke mkpa, dị ka na nkwadebe nke mkpuchi, adhesives na gels. The rheological Njirimara nwere ike ahaziri site n'ịgbanwe ịta na molekụla arọ nke HPMC iji nweta eruba àgwà chọrọ maka kpọmkwem e-jikwaa.
Hydroxypropyl methylcellulose abụrụla polymer dị mkpa na ụlọ ọrụ dị iche iche n'ihi nchikota pụrụ iche nke solubility, viscosity, ikike imepụta ihe nkiri na biocompatibility. Ntugharị ya na-eme ka ọ dị mma maka ngwa dị iche iche, site na ọgwụ na ihe owuwu ihe oriri na ihe ịchọ mma. Ka ndị na-eme nchọpụta na-aga n'ihu na-enyocha usoro na ngwa ọhụrụ, ihe onwunwe nke hydroxypropyl methylcellulose ga-enye aka na ọganihu na mpaghara dị iche iche, na-eme ka ọ nọgide na-adị mkpa na sayensị ihe na ụlọ ọrụ.
Oge nzipu: Jan-10-2024