Hydroxypropyl methylcellulose (HPMC) bụ polymer vasatail nke a na-ejikarị eme ihe na ụlọ ọrụ ọgwụ, karịsịa n'ụdị mbadamba. Dị ka ihe mmepụta cellulose, HPMC nwere ọtụtụ ihe na-arụ ọrụ nke na-enye aka na arụmọrụ mbadamba. A na-enweta ogige ahụ site na cellulose site na usoro mgbanwe nke kemịkalụ, na-eme ka ngwaahịa ndị nwere ihe pụrụ iche dị mma maka ngwa dị iche iche. N'ụdị mbadamba nkume, HPMC nwere ụdị ojiji dị iche iche, gụnyere ịchịkwa ntọhapụ ọgwụ, na-eme ka njikọta mbadamba ihe dịkwuo mma, na ịkwalite nkwụsi ike nke ụdị usoro onunu ogwu.
1. Ndị na-ekekọta na ndị na-ahụ maka granulating:
HPMC na-arụ ọrụ dị ka ihe nkedo n'ụdị mbadamba mbadamba, na-enyere aka ijikọta ihe ndị ahụ ọnụ ma gbochie nkwụsịtụ mbadamba. A na-ejikwa ya dị ka onye na-emepụta ihe na-emepụta ihe n'oge usoro mmepụta ihe, na-enyere ọgwụ ahụ aka na ngwakọta ihe na-emepụta ihe na-emepụta granules.
2. Matrix na-emepụta ihe maka ntọhapụ a na-achịkwa:
Otu n'ime uru kachasị dị na iji HPMC n'ụdị mbadamba mbadamba bụ ikike ya ịchịkwa mwepụta ọgwụ. Mgbe ejiri ya dị ka matriks nke mbụ, HPMC na-etolite matrix gel-dị ka matrix na kọntaktị na mmiri, na-enye ohere maka ntọhapụ ọgwụ na-adịgide adịgide na njikwa. Nke a dị mkpa karịsịa maka ọgwụ ndị nwere windo ọgwụgwọ dị warara ma ọ bụ nke chọrọ ime ogologo oge.
3. Nkewa:
Na mgbakwunye na ọrụ ya dị ka ihe nkedo, HPMC na-arụkwa ọrụ dị ka ihe na-agbasasị n'ụdị mbadamba. Mgbe mbadamba ihe batara na ihe ọṅụṅụ afọ, HPMC na-aza ma na-akpaghasị usoro mbadamba ihe, na-akwalite mwepụta ọgwụ ngwa ngwa. Nke a bara uru karịsịa maka nhazi ntọhapụ ozugbo.
4. Ihe mkpuchi ihe nkiri:
A na-ejikarị HPMC eme ihe mkpuchi ihe nkiri mbadamba. HPMC na-emepụta ihe nkiri na-eme ka ọdịdị mbadamba nkume dịkwuo mma, na-enye nchebe megide ihe ndị metụtara gburugburu ebe obibi, ma nwee ike iji ya mee ihe nkpuchi. Usoro mkpuchi ihe nkiri bụ itinye ihe ngwọta HPMC n'elu mbadamba nkume ma mepụta mkpuchi edo na nke transperent mgbe ihichachara.
5. Njikwa porosity na permeability modifiers:
Mbadamba ụrọ nwere ike ịchọ kpọmkwem porosity na njirimara permeability iji nweta profaịlụ mgbasa nke achọrọ. Enwere ike iji HPMC gbanwee porosity na permeability nke mbadamba, na-emetụta ntọhapụ ọgwụ. Nke a dị oke mkpa iji nweta profaịlụ pharmacokinetic achọrọ nke ọgwụ.
6. Mbadamba mmanu:
HPMC na-arụ ọrụ dị ka ihe mmanu mbadamba nkume, na-ebelata esemokwu n'etiti mbadamba nkume na nhazi akụrụngwa n'oge nrụpụta. Nke a na-eme ka usoro mmepụta mbadamba ihe dị mma ma hụ na mbadamba nkume anaghị arapara na akụrụngwa.
7. Mucoadhesives:
N'ụdị ụfọdụ, ọkachasị maka nnyefe ọgwụ buccal ma ọ bụ ọnụ mucosal, enwere ike iji HPMC mee ihe dị ka onye na-ahụ maka mucoadhesive. Ọ na-enyere aka ịgbatị oge obibi nke ụdị onunu ogwu na elu mucosal, si otú a na-eme ka mmịpụta ọgwụ dịkwuo mma.
8. Ihe nkwalite kwụsie ike:
HPMC na-enyere aka melite nkwụsi ike nke usoro mbadamba nkume site na igbochi mmịpụta mmiri na ichebe ọgwụ ahụ site na ihe gburugburu ebe obibi. Nke a dị mkpa karịsịa maka ọgwụ ndị na-enwe mmetụta nke mmiri mmiri ma ọ bụ na-enwekarị mmebi.
9. Ndakọrịta na ndị ọzọ excipients:
HPMC nwere ezigbo ndakọrịta yana ụdị ihe dị iche iche a na-ejikarị na mbadamba mbadamba. Nkwekọrịta a na-eme ka ọ dị mfe ịmepụta mbadamba nkume nwere ụdị ọgwụ dị iche iche na ihe ndị ọzọ.
Hydroxypropyl methylcellulose (HPMC) na-arụ ọrụ dị mkpa na nhazi mbadamba nkume, na-enye ọtụtụ ọrụ na-enyere aka melite arụmọrụ na ịdị mma nke ụdị usoro onunu ogwu. Ngwa sitere na ndị na-ekekọta ihe na granulating ruo na ndị mbụ matriks ntọhapụ a na-achịkwa, ihe mkpuchi ihe nkiri, mmanụ mmanu na nkwalite nkwụsi ike. Ọdịiche nke HPMC na-eme ka ọ bụrụ ihe bara uru n'ụdị usoro ọgwụ, yana iji ya na-aga n'ihu na-egosipụta mkpa ọ dị n'inweta nsonaazụ nnyefe ọgwụ achọrọ.
Oge nzipu: Dec-25-2023