Hydroxypropyl Methylcellulose Phthalate: kedu ihe ọ bụ

Hydroxypropyl Methylcellulose Phthalate: kedu ihe ọ bụ

Hydroxypropyl Methylcellulose Phthalate(HPMCP) bụ ihe nrụpụta cellulose emezigharịrị nke a na-ejikarị na ụlọ ọrụ ọgwụ. A na-enweta ya na Hydroxypropyl Methylcellulose (HPMC) site na ngbanwe kemịkalụ ọzọ na phthalic anhydride. Mgbanwe a na-enye ihe pụrụ iche na polymer, na-eme ka ọ dị mma maka ngwa dị iche iche na nhazi ọgwụ.

Nke a bụ njirimara na ngwa nke Hydroxypropyl Methylcellulose Phthalate:

  1. mkpuchi ihe na-akpali akpali:
    • A na-eji HPMCP eme ihe n'ọtụtụ ebe dị ka ihe mkpuchi enteric maka ụdị usoro onunu dị ka mbadamba na capsules.
    • A na-emepụta mkpuchi nke enteric iji chebe ọgwụ ahụ site na gburugburu acidic nke afọ ma mee ka a tọhapụ ya na mpaghara alkaline nke obere eriri afọ.
  2. Solubility dabere pH:
    • Otu n'ime ihe pụrụ iche nke HPMCP bụ pH dabere solubility. Ọ na-anọgide na-adịghị ike na gburugburu acidic (pH n'okpuru 5.5) wee ghọọ soluble na alkaline ọnọdụ (pH n'elu 6.0).
    • Ngwongwo a na-enye ohere ka ụdị usoro onunu ogwu ekpuchiri ya gafere n'afọ na-ahapụghị ọgwụ ahụ wee gbazee n'ime eriri afọ maka ịmịnye ọgwụ.
  3. Nguzogide gastric:
    • HPMCP na-enye nguzogide afọ, na-egbochi ịhapụ ọgwụ ahụ n'ime afọ ebe ọ nwere ike imebi ma ọ bụ kpasuo iwe.
  4. Mwepụta a na-achịkwa:
    • Na mgbakwunye na mkpuchi enteric, a na-eji HPMCP na usoro ntọhapụ a na-achịkwa, na-enye ohere maka iwepụta oge ma ọ bụ gbatịa nke ọgwụ ahụ.
  5. ndakọrịta:
    • HPMCP na-adakọkarị na ụdị ọgwụ dịgasị iche iche ma enwere ike iji ya mee ihe n'ụdị ọgwụ dị iche iche.

Ọ dị mkpa iburu n'obi na n'agbanyeghị HPMCP bụ ihe eji eme ihe na-arụ ọrụ nke ọma ma dị irè, nhọrọ nke mkpuchi enteric na-adabere na ihe ndị dị ka ọgwụ a kapịrị ọnụ, profaịlụ ntọhapụ chọrọ, na ihe ndị ọrịa chọrọ. Ndị na-emepụta ihe kwesịrị ịtụle njirimara physicochemical nke ma ọgwụ na ihe mkpuchi enteric iji nweta nsonaazụ ọgwụgwọ a chọrọ.

Dịka ọ dị n'ihe eji eme ọgwụ ọ bụla, a ga-agbaso ụkpụrụ iwu na ụkpụrụ iji hụ na nchekwa, ịdị mma na ịdị mma nke ngwaahịa ọgwụ ikpeazụ. Ọ bụrụ na ị nwere ajụjụ akọwapụtara gbasara ojiji HPMCP n'otu ọnọdụ, a na-atụ aro ka ịkpọtụrụ ntuziaka ọgwụ dị mkpa ma ọ bụ ndị na-ahụ maka njikwa.


Oge nzipu: Jan-22-2024