Hydroxypylththththththylcelllose (hpmc)
Udi: ihe mkpuchi; Ihe eji emechi emechi; Ihe eji eme polymer na-ejikere maka nkwadebe nwayọ. Na-eme ka ihe dị mma; Enyemaka enyemaka, mbadamba mbadamba; Na-akwado nkwado.
1. Ngwa mmeghe ngwaahịa
Ngwaahịa a bụ nke na-abụghị nke ionic ether, na-ahụ dị ka ntụ ntụ ọcha, enweghị ntụ na-enweghị isi, na-agbanye mmiri na mmiri oyi iji kpochapụ ma ọ bụ jiri mmiri colloidal kpochapụ. Ngwọta osisi nwere ọrụ dị elu, nghọta dị elu na arụmọrụ kwụ ọtọ. HPMC nwere ala nke gel. Mgbe kpochara oku, ihe omuma nke ihe omuma di iche iche bu kwa mmiri. Ọnọdụ gel nke nkọwapụta dị iche iche dị iche. Mgbanwe solcosity, viscosity Zhao dị ala, ka ukwuu ịkwado ngụgụ, ihe bara uru na mmiri adịghị emetụta ya.
Ọnọdụ okpomoku nke na-enweghị atụ, tọgbọ chakoo, ezigbo njupụta na mmiri mgbanwe bụ 360 ℃, 0.326G / cm3 na 170 ~ 180 ~ 180 ~ 180 ~ 180 ℃, n'ụzọ dị n'otu. Mgbe kpochara, ọ na-atụgharị aja aja na 190 ~ 200 Celsius na 225 ~ 230 Celsius C.
HPMC bụ ihe a na-ahụkarị na chloroform, ethanol (95%), ngwakọta nke methanol na metylene chloride, na ngwakọta mmiri na ethanol. Ọkwa ụfọdụ nke HPMC na-soluble na agwakọta nke acetone, metylene chloride, na 2-proranol, yana songents ndị ọzọ organic.
Tebụl 1: Ọrụ Nka
arumaru
Gauge,
60 gd (2910).
65GD (2906)
75gd (2208)
Methoxy%
28.0-32.0
27.0-30.0
19.0-24.0
Hydroxypropoxy%
7.0-12.0
4.0-7.5
4.0-12.0
Gel okpomọkụ ℃
56-64.
62.0-68.0
70.0-90.0
Vickosity APA s.
3,5,15,50,50
50400 0
100400 0150 00100 000
Akọrọ Akpọrọ Akpọrọ
5.0 ma ọ bụ obere
Ihe na-enwu ọkụ
1.5 ma ọ bụ obere
pH
4.0-8.0
Ígwè oke
20 ma ọ bụ obere
arsenic
2.0 ma ọ bụ obere
2. Njirimara ngwaahịa
2.1 Hydroxypylthylthylcelllose na-etisasịwo na mmiri oyi iji mepụta ngwọta viodal viodal. Ọ bụrụhaala na agbakwunye ya na mmiri oyi na obere mkpali, enwere ike ịkpụlata ya na ngwọta. Kama nke ahụ, ọ bụ n'ụzọ na-egbochi mmiri ọkụ dị n'elu 60 ℃ ma zaa. Na nkwadebe nke hydroxyl met methicellose nke mmiri hydroposyl metypyl metypyl methicuellose, ma mesịa jiri mmiri oyi na-atụnye ya ka ego achọrọ.
2.2 Hydroxypyl Methylcellose bụ ihe ngwọta na-abụghị ionic na-akwụ ụgwọ, yabụ iji hụ na hpmc anaghị emegharị ihe ndị ọzọ dị mma na usoro nkwadebe mmepụta.
2.3 Hydroxylthylthylthylcelllose nwere ike mgbochi siri ike, yana mmụba nke akara ugo mmụta dị na usoro molecular, anti-ndabara na-emewanyewanye. Iji HPMC dị ka ihe kachasị elu na-enwekwu ogo dị mma n'ime oge dị mma karịa ọgwụ ndị ọzọ na-eji ọdịnala ọdịnala ndị ọzọ (steextrin, dextrin, sugad sursibin).
2.4 hydroxypylthyththth methylcelllose na-agbagharị. Dị ka ọgwụ na-emepụta ọgwụ, ọ naghị atọbi ma ọ bụ nwee obi ụtọ, yabụ na ọ naghị enye ọkụ na ọgwụ na nri. O nwere ngwa puru iche na uru kalori, nnu, nke na - adighi nma na nri na nri maka ndi oria ojoo.
2.5hpmc dịtụsi ike na acid na ntọala, mana ọ bụrụ na ahụ karịrị 2 ~ 11 ma oge nchekwa dị elu, ọ ga-ebelata ogo nke ripenness.
2.6 HydroxypPropyythlthylthylthylththylthyl nwere ike ịnye ọrụ dị elu, na-egosi elu elu na usoro nkwuwa okwu. O nwere emulsification dị irè na usoro ihe abụọ dị iche iche ma enwere ike iji ya dị ka mmachi na colloid dị irè.
2.7 Methypypyl methylcelllose Ashlcelllose Ash nwere ezigbo ihe nkiri, ma bu ezigbo ihe mkpuchi maka mbadamba ihe na ogwu. Membrane guzobere na ya enweghị agba ma sie ike. Ọ bụrụ na agbakwunye Glycel, a ga-aba ụba ya nwere ike ịba ụba. Mgbe ọgwụgwọ ahụ gasịrị, a na-achụsa ngwaahịa a na mmiri oyi, enwere ike ijikwa ọnụego ọnụ site na ịgbanwe ọnụego ya site na ịgbanwe gburugburu Pol. A na-eji ya na-akwado nkwado na-ewepụta nkwado na ntinye aka.
3. Ngwa ahia
3.1. Eji dị ka ihe na-adọrọ adọrọ
A na-eji HPMC eme ihe iji kwalite ọgwụ na-eme ka ọpụpụ, enwere ike ịgbasasị ngwa ngwa dị ka ihe na-edozi ahụ, na-agbada na-adọba ụgbọala na-ejikọ ivu Onye nnọchi anya, na ụdị viscosity maka gluu, naanị iji ụdị dị iche iche na ihe dị iche, izugbe bụ 2% ~ 5%.
Ngwọta Olu nke HPMC na ụfọdụ ithanol ime ihe mgbochi; Ihe atụ: A gwakọtara ya na ngwọta nke abụọ ethanol na-agwakọta maka pelleting nke capsules nke amoxicillin na-abawanye site na 38% ruo 90% na-enweghị HPMC.
Enwere ike iji HPMC mee nke ihe nrapado nwere ihe dị iche iche nke starch slurry mgbe a gbasasịrị. Mpaghara nke erythromycin na-abawanye na mbadamba 38.26% ruo 97.38% mgbe 2% hpmc na 8% starch jikọtara ọnụ.
2.2. Mee ihe nkiri mkpuchi ihe nkiri na ihe nkiri
HPMC dị ka ihe mkpuchi mmiri nwere ihe ndị na-esonụ: Visisitydị nlele anya; Usoro mkpuchi ahụ dị mfe; Ezigbo ihe nkiri na-akpụzi ala; Nwere ike idobe udi nke mpempe ahụ, na-ede ihe; Nwere ike ịbụ mmiri na-a lifedụ; Nwere ike agba, ekpomeekpo ekpo. A na-eji ngwaahịa a dị ka mmiri na-eme mmiri maka mbadamba na ọgwụ dị ala na viscosity na-enweghị mmiri na-enweghị mmiri na-enweghị mmiri na-enweghị mmiri na viocosity dị elu, ọnụego ya bụ 2% -5%.
2.3, dị ka onye na-ahụ maka ihe na-ahụ maka nchekwa na colloidal
Enwere ike iji HPMC mee ihe dị ka onye na-ahụ maka ya bụ 0.45% ~ 1.0%, dị ka anya mmiri na akwa na-adọta ebe ndị na-aga n'ihu; Ejiri iji mee ka nkwụsi ike nke hydrophobic, na-adọba aka, na-ebute ya, ọ bụrụ na usoro onunu ogwu dị 0,5% ~ 1.5%.
2.4, dị ka onye na - egbochi ihe mgbochi, ngwa ngwa ngwa ngwa, na - achịkwa ndị nnọchi anya na onye nnọchi anya PORE
A na-eji ụdị viscosity HPMC dị elu iji kwadebe ihe mgbochi ma na-achịkwa ndị ọrụ ọkpụkpọ ọkpụkpụ nke ọkpụkpụ nke skeleton nwere ike ịnwe mbadamba. Mpempe akwụkwọ viocositty bụ onye nnọchi anya Pụrụ Iche maka mbadamba ma ọ bụ na-achịkwa mbadamba nke ndị dị otú ahụ na-achịkwa ngwa ngwa, na-esochi ma ọ bụ wepụta ma ọ bụ wepụta ya iji nọgide na-achịkwa itinye aka na ọbara.
2.5. Gel na Mattix
Enwere ike ịkwadebe Suftogel na nhazi nke gastric ga-akwadebe site na iji njiri mara hydrogel na-ejikarị ụdị nke HPRMC na-ejikarị.
2.6 Ihe Nta
Agwakọtara Metridazle na hpmc na polycarboxyylene 934 na igwekota ihe iji mee mbadamba akwụkwọ mwepụta nke Boaorosesive nwere 250mg. Na vitro nkewa gosipụtara na nkwadebe a na-efe efe na mmiri, na mgbazinye ọgwụ na-achịkwa ọrịa na-akwụghị ụgwọ na izu ike carbon. Mmejuputa ogbunigwe gosiri na sistemụ ọgwụ mwepụta ọgwụ ọhụrụ ahụ nwere ihe omimi dị omimi na Bovine supling mucosa.
2.7, ka mgbachi enyemaka
Visity viscosity nke ngwaahịa a bụ ezigbo enyemaka nkwụchi kwadebe nkwadebe, ọ na-adịkarị 0,5% ~ 1.5%.
4. Ihe omuma atu
4.1 Ihe nkiri mkpuchi: HPMC 2KG, Talc 2KG, Castor mmanụ 1000ml, Tw000tyyynene Glycol 53000ml, Mmiri 47000ml, Ntuziaka Kwesịrị Ekwentị. E nwere ụzọ abụọ iji mee ya.
4.1.1 Nkwadebe nke akwa akwa akwa akwa mmiri: Tinye ego nke hpmc n'ime 95%, ma ọ bụrụ na ọ bụrụ na ọ dị mkpa), jikọta ihe abụọ na-akpali akpali . Mix 80% nke ihe ngwọta (20% maka Polishing) na-enye ikike nke Castor mmanụ, twoen-80, na proplene glycol.
4.1.2 Nkwadebe nke innoluble pigment (dika iron oxide) a na-etinye ya na 95% ethanol n'otu ntabi anya, a gbakwunyere na mmiri iji mee ntukwasi obi 2%. Emebere ihe ngwọta a maka iji ọgwụ, na-ejikere 80% ụzọ fọdụrụnụ site na mmiri ọkụ mmiri, wee tinye ya na ndenye ọgwụ ndị ọzọ na-agbakwunye ma gwakọtara ọnụ maka ojiji. Usoro mkpuchi nke mkpuchi mkpuchi ahụ: wụsa mpempe akwụkwọ n'ime ite mkpuchi, ị ga - eme ka ọ bụrụ 45 ℃, min, min, mgbe ịpasasịrị, mgbe nkụ Na ikuku na-ekpo ọkụ maka 5 ~ 10min nwere ike isi n'ime ite ahụ, tinye ya na draịra ka ọ kpọọ nkụ karịa 8h.
4.2α-interferton anya 50μg nke αg interfer na 10mlty hydrochloric acid, weere na 90ml ethanol na 0.5HPMC, na-agbanwe ya na 60 ℃ ma kpọnwụọ na ikuku. A na-eme ngwaahịa a na ihe nkiri.
4.3 cotrimoxets mbadamba (0.4G ± 0.08g) 40kg, stachi, 30 na-acha (80 na-eme) 8KG, usoro nkwadebe bụ Gwakọta SMZ na TMP, wee tinye stachi na mix maka 5min. Na preficated 3% hpmc os, ihe dị nro, ya na 10 modonium na-agbakwunye na 14mm gburugburu mbadamba nkume. A na-eji ngwaahịa a dị ka ihe mgbochi. Mgbasa nke mbadamba ahụ bụ 96% / 20min.
44 Piperate Rable (0.25g) Picerate 80 MEsh 25kg, Starch (120 mesh) 2.1kg, magnesium na-eme ka ihe kwesịrị ekwesị. Mpempe akwụkwọ mmepụta ya bụ ịgwakọta acid acid, stachi, nke nwere ihe dị nro, na-agbakwunye na ihuenyo iri na abụọ, na 100mm okirikiri okwu (PPA.25) ) mbadamba nkume. Na stachi dị ka onye na-ekechi ihe, ọnụ ọgụgụ ọnụego mbadamba a adịghị ihe na-erughị 80% / 2min, nke dị elu karịa ngwaahịa ndị yiri ya na Japan.
4.5 keakamere hpmc-4000, HPMC-4500 ma ọ bụ HPMC-5000 0.3g, sodium chloride 0.19g, pedium chloride 0.19g, 10% ammonium gwọọ 0.02mL, mmiri agbakwunyela 100ml. Mmiri mmepụta ya na-etinye na mmiri 15ml, na 80 ~ 100 ℃ mmiri jupụtara na ya, tinye mmiri zuru oke, mgbe ahụ, gwakọtara ọnụ , Jiri nwayọ wụsa feltration, filtrate n'ime akpa akara, nke a na-eji 78 ~ 100 ℃ 8,6 Celsius C.6 Celsius maka ụkọ a, bụ ezigbo dochie anya, Mgbe ejiri ya mee ihe maka microscopy na-egbu egbu, nwere ike mụbaa usoro onunu ogwu nke ngwaahịa a, 0.7% ~ 1.5% dabara adaba.
4,6 methhophone na-achịkwa Meththof na-achịkwa MethhofEf relaten 37.5mg, lapose 40.0MG, 40.0mgrystraline cellilose-102 na magnesium siri ike 2.5mg. A na-akwado ya dị ka mbadamba ihe ọ bụla site na usoro. A na-eji ngwaahịa a dị ka ihe ndị a na-achịkwa.
4.7 maka AVantomycin ⅳ Mbadamba AVantomycin ⅳ monoopydte na 1000m apropropyl mmiri ngwakọta nke 15% (agwakọta, granulated, ma kpọnwụrụ akpọnwụ na 35 ℃. A na-agwakọta veraniles 575G na 62.5G hydropyypropyyloploocellose e-50 jupụtara nke ọma, ma ọ bụ 7.5g steesium acid a na-agbakwunye na mbadamba nkume nke na-aga n'ihu na mbadamba. A na-eji ngwaahịa a dị ka ihe anakọta.
4.8 NIFEDIPED na-atọhapụ Graniles 1 akụkụ NIFEDIPED, Akụkụ 3 Celdypyl (Etylene chloride = 1: 1), na 8 akụkụ carn starch na-emepụta gralules site na ọkara usoro. Ngbanwe ọgwụ nke PH nke PH na-emetụtaghị site na mgbanwe nke PH ma dị nwayọ karịa nke a na-azụ ahịa. Mgbe awa iri na abụọ nke isi, ịta ọbara bụ 12mg / ml, na enweghị ọdịiche dị.
4.9 Profanhaol hydranloride kwagidere convanhaide forranharide 60kg, microcrystalline cellulose 40kG, na-agbakwunye mmiri 50l iji mee ka granules 40k. HPMC1KG na EC 9KG agwakọta na agwakọta sochiri emechi (metylene chloride: E methanol = 15) Mpempe akwụkwọ mm dum, wee jupụta n'ime nkume capsule na-ejupụta igwe. Nke ọ bụla capsule nwere 160mg nke profanolol hydranol hydrochloride sprity.
4.10 Mbadamba HCLLELOL HCLAZEL HCL: HPMC: CPC-na na na na na na na na na na na na na na na na 1: 0.25: 2.25. Ọnụego ọgwụ ntọhapụ ọgwụ ahụ dị nso n'usoro efu n'ime awa iri na abụọ.
Enwere ike iji ọgwụ ndị ọzọ gwakọtara agwakọta ihe ndị ọzọ, dị ka Metoprol: hpmc: cmc-na dị ka: 1: 1.25; AllylProl: HPMC dị ka 1: 2.8: 2.92 ruru. Ọnụego ọgwụ ntọhapụ ọgwụ ahụ dị nso n'usoro efu n'ime awa iri na abụọ.
A kwadebere mbadamba nkume 4.11 kwadebere ihe ndị a gwakọtara agwakọta nke usoro iwu nke usoro iwu si silica gel: cmc-na: HPMC 1: 0.4. Enwere ike ịhapụ ọgwụ ọgwụ maka 12h abụọ na vitro na na vivo, na usoro ntọkọ na lineare nwere mmekọrịta dị mma. Nsonaazụ nke nnwale nkwụsi ike dị ka iwu FDA dị na ndụ nchekwa nke ngwaahịa a dị afọ abụọ.
4.12 HPMC (akụkụ 50MPa) (akụkụ 5), HPMC (4000 mpaghara) na HPC1 akụkụ acetaminophen na 6 akụkụ ahụ dị iche iche silica, na-akpali ya na homogenizer, na spray akpọnwụ. Ngwaahịa a nwere 80% nke ọgwụ bụ isi.
4.13 Mbadamba Glephyline Gydrondon Glely Dị Ikike Mbadamba, 18% -35%, A na-ejikere nke ọma na mbadamba nke hydrophobic, nke nwere ike ịchịkwa mbadamba Nọgide na-etinye ọbara nke ahụ mmadụ maka 12h mgbe onye nchịkwa.
Oge Post: Sepp-20-2022