A na-akpọ HPMC hydroxypropyl methylcellulose.
Ngwaahịa HPMC na-ahọrọ cellulose owu dị ọcha dị ka akụrụngwa ma mee ya site na etherification pụrụ iche n'okpuru ọnọdụ alkaline.Emechara usoro a niile n'okpuru ọnọdụ GMP na nleba anya akpaaka, na-enweghị ihe ọ bụla na-arụ ọrụ dị ka akụkụ anụmanụ na griiz.
Njirimara HPMC:
HPMC ngwaahịa na-abụghị ionic cellulose ether, ọdịdị bụ ọcha ntụ ntụ, odorless keenweghiuto, soluble na mmiri na ọtụtụ pola organic solvents (dị ka dichloroethane) na kwesịrị ekwesị nkezi nke ethanol / mmiri, propyl mmanya / mmiri, wdg Aqueous ngwọta nwere elu. ọrụ, nnukwu nghọta na arụmọrụ kwụsiri ike.HPMC nwere njirimara nke gel thermal, ihe ngwọta mmiri ngwaahịa na-ekpo ọkụ ka ọ bụrụ mmiri ozuzo gel, wee gbazee mgbe ọ dị jụụ, nkọwa dị iche iche nke ngwaahịa gel okpomọkụ dị iche.Solubility na-agbanwe na viscosity, na-ebelata viscosity, nke ukwuu na solubility, dị iche iche nkọwa nke HPMC nwere ụfọdụ ihe dị iche na ya Njirimara, HPMC na mmiri adịghị emetụta PH uru.Oke urughuru: 100 ntupu ngafe ọnụego karịrị 100%.Nnukwu njupụta: 0.25-0.70g/ (na-abụkarị 0.5g/), ike ndọda pụrụ iche 1.26-1.31.Ọnọdụ mgbanwe agba: 190-200 ℃, carbonization okpomọkụ: 280-300 ℃.Esemokwu dị n'elu: 42-56dyn/cm na 2% ngwọta mmiri.Site na mmụba nke methoxyl, ebe gel na-ebelata, solubility mmiri na-abawanye, ọrụ elu na-abawanye.HPMC nwere àgwà nke ndim, salting, obere uyi ọdịnaya, PH nkwụsi ike, mmiri njigide, akụkụ kwụsie ike, magburu onwe film akpụ na nnukwu iguzogide enzyme, disperity na cohesiveness.
Ngwa HPMC:
1. Mbadamba ụrọ: HPMC na-eji dị ka ihe mkpuchi ihe nkiri na nkwadebe siri ike, nwere ike ịmepụta ihe nkiri siri ike, dị nro ma mara mma, ntinye ntinye nke 2% -8%.Mgbe mkpuchi gasịrị, nkwụsi ike nke onye na-ahụ maka ìhè, okpomọkụ na iru mmiri na-abawanye;Enweghị ụtọ na enweghị isi, ọ dị mfe iji, yana pigmenti HPMC, mkpuchi anwụ, mmanụ na ihe ndị ọzọ dị mma.Ihe mkpuchi nkịtị: mmiri ma ọ bụ 30-80% ethanol iji gbarie HPMC, na ngwọta 3-6%, na-agbakwunye ihe enyemaka (dịka: ala okpomọkụ -80, mmanụ castor, PEG400, talc, wdg).
2. Enteric-soluble mkpuchi kewapụrụ oyi akwa: n'elu mbadamba nkume na granules, HPMC mkpuchi na mbụ ji dị ka ala mkpuchi ikewa oyi akwa, na mgbe ahụ, ntekwasa na a oyi akwa nke HPMCP enteric-soluble ihe.Ihe nkiri HPMC nwere ike melite nkwụsi ike nke onye na-ahụ maka mkpuchi ihe na-edozi ahụ na nchekwa.
3. Nkwadebe ntọhapụ na-adịgide adịgide: iji HPMC dị ka onye na-emepụta ihe na-akpata pore na ịdabere na ethyl cellulose dị ka ihe ọkpụkpụ, enwere ike ịmepụta mbadamba nkume na-eme ogologo oge.
4. Thickening gị n'ụlọnga na colloid nchebe nrapado na anya tụlee: HPMC maka ndim gị n'ụlọnga na-ejikarị ịta nke 0.45-1%.
5. Adhesive: HPMC dị ka onye na-ekekọta mkpokọta mkpokọta nke 2% -5%, ejiri mee ka nkwụsi ike nke nrapado hydrophobic, nke a na-ejikarị 0.5-1.5%.
6. Onye na-egbu oge, onye na-ahụ maka ntọhapụ na-achịkwa na onye nkwusioru.Onye nnọchi anya nkwusioru: usoro izizi nke onye nkwusioru bụ 0.5-1.5%.
7. Nri: HPMC dị ka onye na-eme ka ọ dị arọ gbakwunyere na ihe ọṅụṅụ dị iche iche, ngwaahịa mmiri ara ehi, condiments, nri na-edozi ahụ, dị ka onye na-emepụta ihe, ihe nkedo, emulsifier, onye nkwusioru, stabilizer, onye na-ejide mmiri, excifer, wdg.
8. A na-eji ihe ịchọ mma eme ihe dị ka adhesives, emulsifiers, ndị na-emepụta ihe nkiri, wdg.
Oge nzipu: Jan-14-2022