A na-akpọ HPMC hydroxypropyl methylcellulose.
Ngwaahịa HPMC na-ahọrọ cellulose owu dị ọcha dị ka akụrụngwa ma mee ya site na etherification pụrụ iche n'okpuru ọnọdụ alkaline. Emechara usoro a niile n'okpuru ọnọdụ GMP na nleba anya akpaaka, na-enweghị ihe ọ bụla na-arụ ọrụ dị ka akụkụ anụmanụ na griiz.
Njirimara HPMC:
HPMC ngwaahịa na-abụghị ionic cellulose ether, ọdịdị bụ ọcha ntụ ntụ, odorless keenweghiuto, soluble na mmiri na ọtụtụ pola organic solvents (dị ka dichloroethane) na kwesịrị ekwesị nkezi nke ethanol / mmiri, propyl mmanya / mmiri, wdg Aqueous ngwọta nwere elu. ọrụ, nnukwu nghọta na arụmọrụ kwụsiri ike. HPMC nwere ihe onwunwe nke thermal gel, ngwaahịa mmiri ngwọta na-ekpo ọkụ na-etolite jel ọdịda, wee gbazee mgbe jụrụ, dị iche iche nkọwa nke ngwaahịa jel okpomọkụ dị iche iche. Solubility na-agbanwe na viscosity, na-ebelata viscosity, nke ukwuu solubility, dị iche iche nkọwa nke HPMC nwere ụfọdụ ihe dị iche na ya Njirimara, HPMC na mmiri adịghị emetụta PH uru. Oke urughuru: 100 ntupu ọnụego ngafe karịrị 100%. Nnukwu njupụta: 0.25-0.70g/ (na-abụkarị 0.5g/), ike ndọda pụrụ iche 1.26-1.31. Ọnọdụ mgbanwe agba: 190-200 ℃, carbonization okpomọkụ: 280-300 ℃. Esemokwu dị n'elu: 42-56dyn/cm na 2% ngwọta mmiri. Site na mmụba nke ihe methoxyl, ebe gel na-ebelata, solubility mmiri na-abawanye, ọrụ elu na-abawanye. HPMC nwere àgwà nke ndim, nnu, ọdịnaya ash dị ala, nkwụsi ike PH, nkwụsi ike mmiri, nkwụsi ike akụkụ, imepụta ihe nkiri mara mma na nnukwu iguzogide enzyme, disperity na cohesiveness.
Ngwa HPMC:
1. Mbadamba ụrọ: HPMC na-eji dị ka ihe mkpuchi ihe nkiri na nkwadebe siri ike, nwere ike ịmepụta ihe nkiri siri ike, dị nro ma mara mma, ntinye ntinye nke 2% -8%. Mgbe mkpuchi gasịrị, nkwụsi ike nke onye na-ahụ maka ìhè, okpomọkụ na iru mmiri na-abawanye; Enweghị ụtọ na enweghị isi, ọ dị mfe iji, yana pigmenti HPMC, mkpuchi anwụ, mmanụ mmanu na ihe ndị ọzọ dị mma. Ihe mkpuchi nkịtị: mmiri ma ọ bụ 30-80% ethanol iji gbarie HPMC, na ngwọta 3-6%, na-agbakwunye ihe enyemaka (dịka: ala okpomọkụ -80, mmanụ castor, PEG400, talc, wdg).
2. Enteric-soluble mkpuchi kewapụrụ oyi akwa: n'elu mbadamba nkume na granules, HPMC mkpuchi na mbụ ji dị ka ala mkpuchi iche oyi akwa, na mgbe ahụ, ntekwasa na a oyi akwa nke HPMCP enteric-soluble ihe. Ihe nkiri HPMC nwere ike melite nkwụsi ike nke onye na-ahụ maka mkpuchi ihe na-edozi ahụ na nchekwa.
3. Nkwadebe ntọhapụ na-adịgide adịgide: iji HPMC dị ka onye na-emepụta ihe na-akpata pore na ịdabere na ethyl cellulose dị ka ihe ọkpụkpụ, enwere ike ịmepụta mbadamba nkume na-eme ogologo oge.
4. Thickening gị n'ụlọnga na colloid echebe nrapado na anya tụlee: HPMC maka ndim gị n'ụlọnga na-ejikarị ịta nke 0.45-1%.
5. Adhesive: HPMC dị ka onye na-ekekọta mkpokọta mkpokọta nke 2% -5%, nke a na-eji emeziwanye nkwụsi ike nke nrapado hydrophobic, nke a na-ejikarị 0.5-1.5%.
6. Onye na-egbu oge, onye na-ahụ maka ntọhapụ na-achịkwa na onye nkwusioru. Onye nnọchi anya nkwusioru: usoro izizi nke onye nkwusioru bụ 0.5-1.5%.
7. Nri: HPMC dị ka onye na-eme ka ọ dị arọ gbakwunyere na ihe ọṅụṅụ dị iche iche, ngwaahịa mmiri ara ehi, condiments, nri na-edozi ahụ, dị ka onye na-emepụta ihe, ihe nkedo, emulsifier, onye nkwusioru, stabilizer, onye na-ejide mmiri, excifer, wdg.
8. A na-eji ihe ịchọ mma eme ihe dị ka adhesives, emulsifiers, ndị na-emepụta ihe nkiri, wdg.
Oge nzipu: Jan-14-2022