HPMC (hydroxypropyl methylcellulose) bụ thickener na stabilizer nke a na-ejikarị eme ihe ụlọ, mkpuchi, ọgwụ na nri. HPMC 15 cps pụtara na viscosity ya bụ 15 centipoise, nke bụ ọkwa viscosity dị ala.
1. Mụbaa ịta ahụhụ HPMC
Ụzọ kachasị mma ma dị irè iji mee ka viscosity nke HPMC dịkwuo elu bụ ịbawanye ntinye ya na ngwọta. Mgbe oke nha nke HPMC na-abawanye, viscosity nke ngwọta ga-abawanye. Isi nke usoro a bụ na HPMC na-abawanye viscosity nke ngwọta site n'ịmepụta usoro netwọk akụkụ atọ. Ka ọnụ ọgụgụ nke ụmụ irighiri ihe HPMC na ngwọta na-abawanye, njupụta na ike nke usoro netwọk ga-abawanye, si otú ahụ na-amụba viscosity nke ngwọta. Otú ọ dị, enwere oke na ịba ụba itinye uche. Nnukwu ntinye uche nke HPMC ga-eme ka mmiri nke ngwọta na-ebelata, ma nwee ike imetụta arụmọrụ ya na ngwa ngwa, dị ka ihe owuwu na ịrụ ọrụ.
2. Jikwaa okpomọkụ nke ngwọta
Okpomọkụ nwere mmetụta dị ukwuu na solubility na viscosity nke HPMC. Na obere okpomọkụ, viscosity nke HPMC ngwọta dị elu; mgbe na elu okpomọkụ, viscosity nke HPMC ngwọta ga-ebelata. Ya mere, iweda ọnọdụ okpomọkụ nke ngwọta nke ọma n'oge eji eme ihe nwere ike ime ka viscosity nke HPMC dịkwuo elu. Ekwesiri iburu n'uche na solubility nke HPMC na ngwọta dị iche iche na okpomọkụ dị iche iche. Ọ na-adịkarị mfe ịgbasa na mmiri oyi, mana ọ na-ewe oge ụfọdụ iji gbazee kpamkpam. Ọ na-agbaze ngwa ngwa na mmiri ọkụ, mana viscosity dị ala.
3. Gbanwee uru pH nke ihe mgbaze
Viscosity nke HPMC na-enwekwa mmetụta maka uru pH nke ngwọta ahụ. N'okpuru ọnọdụ na-anọpụ iche ma ọ bụ nso-anọpụ iche, viscosity nke ngwọta HPMC bụ nke kachasị elu. Ọ bụrụ na uru pH nke ngwọta na-apụ na nnọpụiche, viscosity nwere ike ibelata. Ya mere, viscosity nke ngwọta HPMC nwere ike ịba ụba site n'ịgbanwe nke ọma pH uru nke ngwọta (dịka ọmụmaatụ, site na ịgbakwunye ihe nchekwa ma ọ bụ onye na-ahụ maka acid-base). Otú ọ dị, na arụ ọrụ n'ezie, ngbanwe nke uru pH kwesịrị ịkpachara anya, n'ihi na nnukwu mgbanwe nwere ike ịkpata mmebi HPMC ma ọ bụ mmebi arụmọrụ.
4. Họrọ ihe mgbaze kwesịrị ekwesị
The solubility na viscosity nke HPMC dị iche iche ihe mgbaze usoro dị iche iche. Ọ bụ ezie na a na-ejikarị HPMC eme ihe na ngwọta mmiri, mgbakwunye nke ụfọdụ ihe mgbaze organic (dị ka ethanol, isopropanol, wdg) ma ọ bụ nnu dị iche iche nwere ike ịgbanwe usoro nhazi nke molekul HPMC, si otú ahụ na-emetụta viscosity. Dịka ọmụmaatụ, ntakịrị ihe mgbaze organic nwere ike ibelata nnyonye anya nke ụmụ irighiri mmiri na HPMC, si otú ahụ na-abawanye viscosity nke ngwọta. Na arụmọrụ kpọmkwem, ọ dị mkpa ịhọrọ ihe mgbaze organic kwesịrị ekwesị dịka ngwa ngwa ahụ si dị.
5. Jiri ihe ndị na-emekọ ihe
N'ọnọdụ ụfọdụ, enwere ike ịgbakwunye ihe enyemaka ndị ọzọ na-ebuwanye ibu na HPMC iji nweta mmetụta nke ịba ụba viscosity. Ihe mgbakwunye ndị a na-ejikarị eme ihe na-agụnye xanthan chịngọm, guar gum, carbomer, wdg. Ihe mgbakwunye ndị a na-ejikọta mkpụrụ ndụ HPMC na-emepụta gel ma ọ bụ netwọk siri ike karị, na-abawanye viscosity nke ngwọta. Dịka ọmụmaatụ, xanthan chịngọm bụ polysaccharide eke nwere mmetụta siri ike. Mgbe eji na HPMC, ha abụọ nwere ike na-etolite a synergistic mmetụta na budata dịkwuo viscosity nke usoro.
6. Gbanwee ogo nke nnọchi nke HPMC
The viscosity nke HPMC na-metụtakwara ogo nke nnọchi nke methoxy na hydroxypropoxy otu ya. Ogo nke nnọchi na-emetụta solubility ya na viscosity nke ngwọta. Site na ịhọrọ HPMC nwere ogo dị iche iche nke nnọchi, enwere ike idozi viscosity nke ngwọta. Ọ bụrụ na achọrọ HPMC viscosity dị elu, enwere ike ịhọrọ ngwaahịa nwere ọdịnaya methoxy dị elu, n'ihi na ọdịnaya methoxy dị elu, ka hydrophobicity nke HPMC na-esiwanye ike, na viscosity mgbe mgbasa dị oke elu.
7. Gbatịkwuo oge mgbasa
Oge HPMC ga-agbaze ga-emetụtakwa viscosity ya. Ọ bụrụ na HPMC adịghị agbaze kpamkpam, viscosity nke ngwọta agaghị eru ezigbo ala. Ya mere, n'ụzọ kwesịrị ekwesị ịgbatị oge mgbasa nke HPMC na mmiri iji hụ na HPMC bụ kpamkpam hydrated nwere ike n'ụzọ dị irè dịkwuo viscosity nke ngwọta ya. Karịsịa mgbe agbazere na obere okpomọkụ, usoro mgbasa HPMC nwere ike ịdị nwayọ, yana ịgbatị oge dị oke mkpa.
8. Gbanwee ọnọdụ ịkwa akwa
Viscosity nke HPMC na-emetụtakwa ike shii a na-edobere n'oge eji. N'okpuru ọnọdụ dị elu, viscosity nke ngwọta HPMC ga-ebelata nwa oge, ma mgbe shear kwụsịrị, viscosity ga-agbake. Maka usoro ndị na-achọ ịba ụba viscosity, ike ịkpụ nke ihe ngwọta na-edozi nwere ike ibelata, ma ọ bụ na-arụ ọrụ n'okpuru ọnọdụ dị ala dị ala iji nọgide na-enwe viscosity dị elu.
9. Họrọ ezigbo ibu molekụla
The molekụla arọ nke HPMC na-emetụta ya viscosity ozugbo. HPMC nwere ibu molekul buru ibu na-etolite usoro netwọkụ buru ibu na ngwọta, na-ebute viscosity dị elu. Ọ bụrụ na ịchọrọ ịbawanye viscosity nke HPMC, ị nwere ike ịhọrọ ngwaahịa HPMC nwere oke molekụla dị elu. Ọ bụ ezie na HPMC 15 cps bụ ngwaahịa viscosity dị ala, enwere ike ịbawanye viscosity site na ịhọrọ ụdị dị elu-molecular arọ nke otu ngwaahịa ahụ.
10. Tụlee ihe gbasara gburugburu ebe obibi
Ihe gbasara gburugburu ebe obibi dị ka iru mmiri na nrụgide nwekwara ike inwe mmetụta ụfọdụ na viscosity nke ngwọta HPMC. N'ebe oke iru mmiri dị elu, HPMC nwere ike ịmịkọrọ mmiri sitere na ikuku, na-eme ka viscosity ya belata. Iji zere nke a, enwere ike ịchịkwa ọnọdụ gburugburu ebe obibi nke mmepụta ma ọ bụ saịtị eji eme ihe nke ọma iji mee ka gburugburu ebe akọrọ na nrụgide kwesịrị ekwesị iji nọgide na-enwe viscosity nke ngwọta HPMC.
E nwere ọtụtụ ụzọ dịkwuo viscosity nke HPMC 15 cps ngwọta, gụnyere ịba ụba ịta, ịchịkwa okpomọkụ, ukpụhọde pH, na-eji ndim AIDS, na-ahọpụta kwesịrị ekwesị n'ókè nke nnọchi na molekụla arọ, wdg The kpọmkwem usoro a ga-ahọrọ na-adabere n'ezie ngwa. dịruru ná njọ na usoro chọrọ. N'ime ọrụ n'ezie, ọ na-adịkarị mkpa iji nlezianya tụlee ọtụtụ ihe ma mee mgbanwe ezi uche na njikarịcha iji hụ na arụmọrụ kachasị mma nke ngwọta HPMC na ngwa ngwa.
Oge nzipu: Ọktoba 16-2024