Hydroxypyl Methylcellose (HPMC) bụ ihe eji eme ihe eji eme ihe eji eme ihe, dịka ọgwụ, nri, ihe eji eme ihe na ihe ịchọ mma. HPMC bụ ihe na-abụghị Ionic, ọkara ụlọ, na polymer nwere ezigbo mmiri solbality, ndị na-eme ihe na akụrụngwa na-akpụ akpụ.
Ọdịdị na Njirimara nke HPMC
HPMC bụ ihe mgbazinye na-emepụta site na imegharị sellulose na metyl chloride na proflene oxide. Ihe owuwu molecular nwere ma methyl na hydroxylyl, nke na-enye HPMC ihe ngosi anụ ahụ na kemịkalụ, dị ka ezigbo soft, nchebe nchebe na akụrụngwa na-akpụ akpụ. Enwere ike ekewa HPMC n'ọtụtụ nkọwa dị ka ndị nnọchi anya dị iche iche, nkọwa ọ bụla nwere ka akụkụ dị iche iche ma na-eji mmiri.
Solublity nke hpmc na mmiri
Usoro a na-efe efe
Mmekọrịta HPMC nwere ụmụ irighiri mmiri site na ijikọ hydrogen iji mepụta ihe ngwọta. Usoro ya na-agụnye gụnyere ụmụ irighiri mmiri na-eji nwayọọ nwayọọ banye n'ime eriri ahụ nke hpmc, na-emebi cohesion ya, nke mere na mkpụrụ osisi polymer sochirinụ na-etolite otu usoro iji mepụta otu. Mgbalị nke HPMC nwere njikọ chiri anya na oke molecular, ụdị dị mma na ogo nke dochie (DS). N'ozuzu, onye dị elu nke nbanye nke rụrụ arụ, onye dị elu solublity nke hpmc na mmiri.
Mmetụta nke okpomọkụ na solublity
Ọnọdụ okpomọkụ bụ otu n'ime ihe dị mkpa na-emetụta ngbasa nke HPMC. Mgbalị nke Hpmc na mmiri na-egosi njirimara dị iche iche dịka ọnọdụ mgbanwe:
Ọnọdụ okpomọkụ: HPMC siri ike ịgbafe na mmiri oyi (n'ozuzu n'okpuru 40 Celsius C), ma ọ nwere ike ịgbari ọsọsọ mgbe o wusiri ike ruo 60 Celsius C ma ọ bụ karịa. N'ihi na viscosity dị ala, mmiri okpomọkụ nke ihe dị ka 60 Celsius C na-abụkarị ezigbo ọnọdụ okpomọkụ. Maka ndị visa viscosity HPMC, ezigbo ọnọdụ okpomọkụ nwere ike ịdị ka 80 Celsius C.
GELAtion n'oge jụrụ: Mgbe HPMC ihe ngwọta na-ewe iwe maka ụfọdụ okpomọkụ (ọ na-abụkarị 60-80 ° C) Mgbe a ga-akpụzi jel gel. Nke a na-eme ihe ọkụ na-aghọ kwụsiri ike mgbe oyi jụrụ na ụlọ okpomọkụ ma nwee ike ịgbanwe ya na mmiri oyi. Ihe a dị ezigbo mkpa maka nkwadebe nke azịza HPMC maka ụfọdụ ebumnuche (dịka ọgwụ a na-eme ka mkpụrụ akwụkwọ debere ya).
Asationdị na-adịghị ahụkebe: n'ozuzu, okpomọkụ dị elu nwere ike ime ka usoro a na-aga nke HPMC. Agbanyeghị, oke okpomọkụ nwekwara ike iduba na mmebi nke polymer ma ọ bụ mbelata nke mgbasa ozi. Ya mere, na arụ ọrụ n'ezie, a ga-ahọpụta ọnọdụ okpomọkụ dị mkpa iji zere mmebi na-enweghị mgbanwe na ihe onwunwe.
Mmetụta nke ph na solublity
Dị ka polymer na-abụghị nke Ionic, solub na mmiri na mmiri adịghị emetụta uru nke ph uru nke ya. Agbanyeghị, ọnọdụ plọ dị egwu (dịka gburugburu acidic ma ọ bụ gburugburu alkaline siri ike) nwere ike imetụta njirimara nke HPMC:
Ọnọdụ ndị acidic: n'okpuru ọnọdụ acidic siri ike (ph <3), ụfọdụ ndị na-eme acidic (nke si na-emetụtakwa solubality na ndọgbu ya. Agbanyeghị, na General na-adịghị ike acid nke (PH 3-6), HPMC ka nwere ike ịbụ nke ọma. Ọnọdụ alkaline: N'okpuru ọnọdụ alkaline (pH> 11), HPMC nwere ike ịrara, nke na-abụkarị n'ihi mmeghachi omume hydrolypyl nke hydrolysis. N'okpuru ọnọdụ alkaline (PH 7-9), solub na hpmc anaghị emetụta nke ọma.
Anzọ HPMC
Iji igbari hpmc, a na-ejikarị ụzọ ndị a:
Usoro mgbasa mmiri oyi: Jiri nwayọ tinye ntụ ntụ hpmc n'ime mmiri oyi mgbe ị na-akpali ya iji gbasaa ya. Usoro a nwere ike igbochi HPMC site na aglomerating na mmiri, ma ihe ngwọta ya na-etolite oyi akwa colloidal. Mgbe ahụ, jiri nwayọ kpoo ya ọkụ ruo 60-80 ° C ka igbari ya. Usoro a dabara adaba maka mgbasa nke ọtụtụ HPMC.
Usoro mgbasa mmiri na-ekpo ọkụ: Tinye Hpmc ka mmiri ọkụ ma kpagbuo ya ngwa ngwa igbari ya ngwa ngwa na okpomọkụ dị elu. Usoro a dabara adaba maka viscosity HPMC, mana ekwesịrị ịkwụghachi ya iji chịkwaa ọnọdụ okpomọkụ iji zere mmebi.
Ngwọta Pụrụ Iche: Nke mbụ, HPMC a na-agbaze na mgbaze organic (dị ka ethanol), wee tinye mmiri nke nta nke nta nke nta nke nta nke nta gbakwụnye ya n'ime ihe ọ bụla. Usoro a dabara adaba maka ọnọdụ ngwa pụrụ iche na-enyere anyị aka dị elu.
Ndọpụta omume na ngwa ndị bara uru
N'ime ihe bara uru, usoro nsị nke HPMC kwesịrị ka e nweli ya ka ojiji ndị akọwapụtara. Iji maa atụ, na mpaghara ọgwụ, ọ na-adịkarị mkpa iji mepụta usoro na-edo edo na nke kwụsiri ike, yana nchịkwa ike nke okpomọkụ na pH dị ka ọrụ dị omimi nke ihe ngwọta. N'ime ihe eji eme ihe, solubility hpmc na-emetụta ihe ngosi na-akpụ akpụ na ike na-eme ihe nkiri, yabụ na-enweghị ike ịhọpụta ụzọ kachasị mma na ọnọdụ gburugburu ebe obibi akọwapụtara.
Otutu solution na mmiri na-emetụta ọtụtụ ihe, na-emetụta ọnọdụ na pH. N'ikwu okwu, HPMC agbasasịwo ngwa ngwa na elu okpomọkụ (60-80 Celsius C), mana ọ nwere ike mebie ma ọ bụ bụrụ onye na-adịghị ala ala n'okpuru oke plọn. Ya mere, na ngwa bara uru, ọ dị mkpa ịhọrọ okpomọkụ na ogo nke ekwesị dị ka iji ya na ọnọdụ gburugburu hpmc iji hụ na ọ dị mma na arụmọrụ ya na arụmọrụ ya.
Oge post: Jun-25-2024