Hydroxypropyl Methylcellulose (HPMC) bụ ihe a na-ejikarị cellulose eme ihe nwere ngwa dị iche iche, dị ka ọgwụ, nri, ihe ụlọ na ihe ịchọ mma. HPMC bụ ihe na-abụghị ionic, semi-synthetic, polymer inert nwere ezigbo mmiri solubility, ịgba, nrapado na ihe na-emepụta ihe nkiri.
Ọdịdị na Njirimara nke HPMC
HPMC bụ cellulose emezigharịrị emepụtara site n'imeghachi cellulose na methyl chloride na propylene oxide. Ọdịdị molekụla ya nwere ma methyl na hydroxypropyl substituents, nke na-enye HPMC pụrụ iche anụ ahụ na kemịkal Njirimara, dị ka magburu onwe solubility, colloid nchebe na film-akpụ Njirimara. Enwere ike kewaa HPMC n'ọtụtụ nkọwa dị ka ihe nnọchi anya dị iche iche si dị, nkọwapụta nke ọ bụla nwere solubility na ojiji dị iche iche na mmiri.
Solubility nke HPMC na mmiri
Usoro mgbasa
HPMC na-emekọrịta ihe na ụmụ irighiri mmiri site na njikọ hydrogen iji mepụta ngwọta. Usoro mgbasa ya na-agụnye ụmụ irighiri mmiri na-eji nwayọọ nwayọọ na-abanye n'etiti agbụ molekul nke HPMC, na-ebibi njikọ ya, nke mere na ụdọ polymer na-agbasa n'ime mmiri iji mepụta ngwọta edozi. Solubility nke HPMC nwere njikọ chiri anya na ịdị arọ molekụla ya, ụdị nnọchi na ogo nnọchi (DS). N'ozuzu, elu ogo nke nnọchi nke nnọchi anya, na elu solubility nke HPMC na mmiri.
Mmetụta okpomọkụ na solubility
Okpomọkụ bụ otu n'ime ihe ndị dị mkpa na-emetụta solubility nke HPMC. Solubility nke HPMC n'ime mmiri na-egosi njirimara dị iche iche ka okpomọkụ na-agbanwe:
Mgbasa okpomọkụ nso: HPMC na-esi ike igbari na mmiri oyi (n'ozuzu n'okpuru 40°C), ma ọ nwere ike igbari ngwa ngwa mgbe okpomọkụ ka 60°C ma ọ bụ karịa. Maka HPMC nwere viscosity dị ala, okpomoku mmiri dị ihe dịka 60°C na-abụkarị okpomoku mgbaze kacha mma. Maka HPMC nwere viscosity dị elu, oke okpomọkụ mgbasa kacha mma nwere ike ịdị elu ruo 80°C.
Gelation n'oge jụrụ oyi: Mgbe HPMC ngwọta na-ekpo ọkụ na ụfọdụ okpomọkụ (na-emekarị 60-80 Celsius C) n'oge mgbasa na mgbe ahụ nwayọọ nwayọọ jụrụ, a thermal gel ga-emepụta. Gel a na-ekpo ọkụ na-eguzosi ike mgbe ọ jụrụ n'ime ụlọ ma nwee ike ịgbasa ya na mmiri oyi. Ihe omume a dị oke mkpa maka nkwadebe nke ngwọta HPMC maka ụfọdụ ebumnuche (dị ka capsules na-adịgide adịgide).
Ịrụ ọrụ mgbasa: N'ozuzu, okpomọkụ dị elu nwere ike ime ka usoro mgbasa nke HPMC dịkwuo ngwa. Agbanyeghị, oke okpomọkụ nwekwara ike bute mmebi polymer ma ọ bụ mbelata viscosity mgbasa. Ya mere, n'ime ọrụ n'ezie, a ga-ahọrọ okpomọkụ nkwụsị kwesịrị ekwesị dị ka ọ dị mkpa iji zere mmebi na-enweghị isi na mgbanwe ihe onwunwe.
Mmetụta nke pH na solubility
Dị ka polymer na-abụghị ionic, solubility nke HPMC na mmiri adịghị emetụta kpọmkwem pH uru nke ngwọta. Agbanyeghị, ọnọdụ pH siri ike (dịka gburugburu acidic ma ọ bụ alkaline siri ike) nwere ike imetụta njirimara mgbasa nke HPMC:
Ọnọdụ acidic: N'okpuru ọnọdụ acidic siri ike (pH <3), ụfọdụ njikọ kemịkalụ nke HPMC (dị ka ether agbụ) nwere ike ibibi site na ọkara acidic, si otú ahụ na-emetụta solubility na dispersibility ya. Agbanyeghị, na oke acid adịghị ike (pH 3-6), HPMC ka nwere ike gbazee nke ọma. Ọnọdụ alkaline: N'okpuru ọnọdụ alkaline siri ike (pH> 11), HPMC nwere ike imebi, nke na-abụkarị n'ihi mmeghachi omume hydrolysis nke agbụ hydroxypropyl. N'okpuru ọnọdụ alkaline na-adịghị ike (pH 7-9), a naghị emetụta solubility nke HPMC.
Usoro mgbasa nke HPMC
Iji gbarie HPMC nke ọma, a na-ejikarị ụzọ ndị a:
Ụzọ mgbasa mmiri oyi: Jiri nwayọọ tinye HPMC ntụ ntụ n'ime mmiri oyi ka ị na-akpali agbasa ka ọ gbasaa. Usoro a nwere ike igbochi HPMC ozugbo agglomerating na mmiri, na ngwọta na-etolite a colloidal nchebe oyi akwa. Mgbe ahụ, jiri nwayọọ nwayọọ kpoo ya ruo 60-80 ° C ka ọ gbazee ya kpamkpam. Usoro a dabara adaba maka mgbasa nke ọtụtụ HPMC.
Usoro ịgbasa mmiri ọkụ: Tinye HPMC na mmiri ọkụ wee kpalite ya ngwa ngwa ka igbari ya ngwa ngwa na oke okpomọkụ. Usoro a dabara adaba maka HPMC nwere viscosity dị elu, mana ekwesịrị itinye nlebara anya na njikwa okpomọkụ iji zere mmebi.
Ngwọta tupu usoro nkwadebe: Nke mbụ, HPMC na-agbaze na ihe mgbaze organic (dị ka ethanol), wee jiri nwayọọ nwayọọ tinye mmiri iji mee ka ọ ghọọ ngwọta mmiri. Usoro a dabara adaba maka ihe ngosi ngwa pụrụ iche nwere oke solubility chọrọ.
Omume mgbasa ozi na ngwa bara uru
N'ime ngwa bara uru, a ga-emeziwanye usoro mgbasa nke HPMC dịka ojiji a kapịrị ọnụ. Dịka ọmụmaatụ, na mpaghara ọgwụ, ọ na-adịkarị mkpa ịmepụta ihe ngwọta colloidal dị oke mma na nke kwụsiri ike, na njikwa siri ike nke okpomọkụ na pH chọrọ iji hụ na viscosity na ọrụ ndu nke ngwọta. N'ime ihe owuwu ụlọ, solubility nke HPMC na-emetụta ihe ndị na-emepụta ihe nkiri na ike mkpakọ, n'ihi ya, ọ dị mkpa ka a họrọ usoro mgbasa ozi kacha mma na-ejikọta ya na ọnọdụ gburugburu ebe obibi.
Solubility nke HPMC na mmiri na-emetụta ọtụtụ ihe, karịsịa okpomọkụ na pH. N'ikwu okwu n'ozuzu, HPMC na-agbaze ngwa ngwa na okpomọkụ dị elu (60-80 Celsius C), mana ọ nwere ike wedata ma ọ bụ ghọọ nke na-esighị ike n'okpuru ọnọdụ pH dị oke egwu. Ya mere, n'ime ngwa bara uru, ọ dị mkpa ịhọrọ okpomọkụ nkwụsị nke kwesịrị ekwesị na pH dị ka ihe eji eme ihe na ọnọdụ gburugburu ebe obibi nke HPMC iji hụ na ọ dị mma solubility na arụmọrụ.
Oge nzipu: Jun-25-2024