Hydroxypropyl methylcellulose, nke a na-akpọkarị HPMC, bụ ihe mgbakwunye ọgwụ na mgbakwunye nri. N'ihi oke solubility ya, ikike njide na ihe na-emepụta ihe nkiri, ejirila ya mee ihe na ụlọ ọrụ ọgwụ. A na-ejikwa HPMC eme ihe na ụlọ ọrụ nri dị ka thickener, emulsifier na stabilizer. Ịdị ọcha nke HPMC dị oke mkpa na ụlọ ọrụ ọgwụ na nri dịka ọ na-emetụta arụmọrụ na nchekwa nke ngwaahịa ahụ. Isiokwu a ga-atụle mkpebi siri ike nke ịdị ọcha HPMC na ụzọ ya.
Kedu ihe bụ HPMCs?
Hydroxypropylmethylcellulose (HPMC) bụ ether cellulose sitere na methylcellulose. Ibu molekụla ya dị 10,000 ruo 1,000,000 Dalton, ọ bụkwa ntụ ọcha ma ọ bụ na-acha ọcha, enweghị isi na enweghị ụtọ. HPMC na-adị mfe mgbaze na mmiri, yana soluble na ụfọdụ ihe mgbaze organic dị ka ethanol, butanol, na chloroform. O nwere ụfọdụ ihe pụrụ iche dị ka njide mmiri, ike na-agbakọ ma na-ejikọta ya, nke na-eme ka ọ dị mma maka ụlọ ọrụ ọgwụ na nri.
Mkpebi nke ịdị ọcha HPMC
Ịdị ọcha nke HPMC dabere n'ọtụtụ ihe dịka ogo nnọchi (DS), ọdịnaya mmiri na ọdịnaya ntụ. DS na-anọchi anya ọnụọgụ nke otu hydroxyl ndị otu hydroxypropyl nọchiri n'ime molekul cellulose. Ọkwa dị elu nke nnọchi na-abawanye solubility nke HPMC ma na-eme ka ikike imepụta ihe nkiri dịkwuo mma. N'aka nke ọzọ, ngbanwe dị ala ga-ebute mbelata solubility na ihe ndị na-emepụta ihe nkiri na-adịghị mma.
Usoro mkpebi ịdị ọcha nke HPMC
Enwere ụzọ dị iche iche maka ịchọpụta ịdị ọcha nke HPMC, gụnyere titration acid-base, nyocha elemental, chromatography mmiri na-arụ ọrụ dị elu (HPLC), na infrared spectroscopy (IR). Nke a bụ nkọwa maka usoro ọ bụla:
acid-base titration
Usoro a dabere na mmeghachi omume neutralization n'etiti acidic na isi otu na HPMC. Nke mbụ, a na-agbaze HPMC n'ime ihe mgbaze na a na-agbakwunye olu amaara nke acid ma ọ bụ isi ngwọta nke ntinye amaara. Emere titration ruo mgbe pH ruru ebe na-anọpụ iche. Site na ọnụọgụ acid ma ọ bụ ntọala riri, enwere ike gbakọọ ogo nnọchi anya.
Nyocha nke ihe
Nyocha nke elementrị na-atụle pasentị nke ihe ọ bụla dị na nlele, gụnyere carbon, hydrogen, na oxygen. Enwere ike ịgbakọ ogo ngbanwe site na ọnụọgụ nke ihe ọ bụla dị na nlele HPMC.
Chromatography Liquid Na-arụ Ọrụ Dị Elu (HPLC)
HPLC bụ usoro nyocha nke a na-ejikarị eme ihe nke na-ekewa ihe mejupụtara ngwakọta dabere na mmekọrịta ha na usoro kwụ ọtọ na nke mkpanaka. Na HPMC, enwere ike gbakọọ ogo ngbanwe site n'ịtụ nha hydroxypropyl na otu methyl na nlele.
Infrared Spectroscopy (IR)
Infrared spectroscopy bụ usoro nyocha nke na-atụ nnabata ma ọ bụ nnyefe nke radieshon infrared site na nlele. HPMC nwere ọnụ ọnụ nnabata dị iche iche maka hydroxyl, methyl na hydroxypropyl, nke enwere ike iji chọpụta ogo nnọchi.
Ịdị ọcha nke HPMC dị oke egwu na ụlọ ọrụ ọgwụ na nri nri, na mkpebi ya dị oke mkpa iji hụ na nchekwa na ịdị irè nke ngwaahịa ikpeazụ. Ọtụtụ ụzọ dị iji chọpụta ịdị ọcha nke HPMC, gụnyere titration acid-base, elemental analysis, HPLC, and IR. Usoro ọ bụla nwere uru na ọghọm ya ma nwee ike họrọ ya dịka ihe achọrọ nke ngwa ahụ. Iji nọgide na-adị ọcha nke HPMC, a ga-echekwa ya n'ebe kpọrọ nkụ, dị jụụ na-adịghị na ìhè anyanwụ na ihe ndị ọzọ na-emerụ emerụ.
Oge nzipu: Ọgọst-25-2023